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PolyUb-K109-FBXL7 [cytosol]
Stable Identifier
R-HSA-8854053
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G2-G2/M phases (Homo sapiens)
G2/M Transition (Homo sapiens)
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis (Homo sapiens)
Proteasome-mediated degradation of PolyUb-FBXL7 (Homo sapiens)
PolyUb-K109-FBXL7 [cytosol] (Homo sapiens)
SCF-FBXL18 ubiquitinates FBXL7 (Homo sapiens)
PolyUb-K109-FBXL7 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UJT9 FBXL7
Gene Names
FBXL7, FBL6, FBL7, KIAA0840
Chain
chain:1-491
Reference Genes
BioGPS Gene:23194 FBXL7
COSMIC (genes):FBXL7 FBXL7
CTD Gene:23194 FBXL7
dbSNP Gene:23194 FBXL7
ENSEMBL:ENSG00000183580 FBXL7
HGNC:13604 FBXL7
KEGG:hsa:23194 FBXL7
Monarch:23194 FBXL7
NCBI Gene:23194 FBXL7
OMIM:605656 FBXL7
UCSC:Q9UJT9 FBXL7
Reference Transcript
RefSeq:NM_001278317.1 FBXL7
RefSeq:NM_012304.4 FBXL7
RefSeq:XM_011513998.1 FBXL7
Other Identifiers
11721378_at
11752259_a_at
11756659_a_at
16983412
213249_PM_at
213249_at
23194
2802964
2802965
2802966
2802967
2802968
2802997
2803074
2803075
2803076
2803078
2803079
2803080
2803081
37205_at
8104592
A_14_P132622
A_23_P144827
A_24_P7600
GE53533
GO:0000086
GO:0000151
GO:0000209
GO:0000278
GO:0005515
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0006511
GO:0016567
GO:0019005
GO:0030163
GO:0031146
GO:0043226
GO:0051301
HMNXSV003013245
Hs.76798.0.S2_3p_at
ILMN_1705035
PH_hs_0004430
TC05000088.hg
Participates
as an output of
SCF-FBXL18 ubiquitinates FBXL7 (Homo sapiens)
as an input of
Proteasome-mediated degradation of PolyUb-FBXL7 (Homo sapiens)
Other forms of this molecule
FBXL7 [cytosol]
Inferred To
Fbxl7 [cytosol]
(Drosophila melanogaster)
Fbxl7 [cytosol]
(Mus musculus)
Fbxl7 [cytosol]
(Rattus norvegicus)
PolyUb-K109-FBXL7 [cytosol]
(Plasmodium falciparum)
PolyUb-K109-FBXL7 [cytosol]
(Saccharomyces cerevisiae)
FBXL7 [cytosol]
(Bos taurus)
FBXL7 [cytosol]
(Canis familiaris)
FBXL7 [cytosol]
(Gallus gallus)
FBXL7 [cytosol]
(Sus scrofa)
Homologues of PolyUb-K109-FBXL7 [cytosol]
(Saccharomyces cerevisiae)
fbxl7 [cytosol]
(Danio rerio)
Modified Residues
Name
ubiquitinylated lysine (polyubiquitin chain [cytosol]) at 109
Coordinate
109
Modification
polyubiquitin chain [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
ENSEMBL
ENST00000504595
,
ENSG00000183580
,
ENSP00000423630
,
ENST00000510662
,
ENSP00000425184
OpenTargets
ENSG00000183580
GeneCards
FBXL7
HPA
ENSG00000183580-FBXL7
PRO
Q9UJT9
Pharos - Targets
Q9UJT9
GlyGen
Q9UJT9
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:A0A0C3SFZ9 A0A0C3SFZ9
0.556
3
UniProt:Q92609 TBCD5
0.556
3
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