Plasma membrane FGFR1 fusions autophosphorylate

Stable Identifier
R-HSA-8853325
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Although it hasn't been directly demonstrated in all cases, the ability to promote transformation and anchorage independent growth suggests these fusions undergo autophosphorylation similar to WT FGFR1 proteins. Indeed, active kinase activity has been demonstrated for the the ERLIN2-FGFR1 fusion identified in breast cancer (Singh et al, 2012; Wu et al, 2013; Wang et al, 2014; reviewed in Parker et al, 2014)

Literature References
PubMed ID Title Journal Year
22837387 Transforming fusions of FGFR and TACC genes in human glioblastoma

Singh, D, Chan, JM, Zoppoli, P, Niola, F, Sullivan, R, Castano, A, Liu, EM, Reichel, J, Porrati, P, Pellegatta, S, Qiu, K, Gao, Z, Ceccarelli, M, Riccardi, R, Brat, DJ, Guha, A, Aldape, K, Golfinos, JG, Zagzag, D, Mikkelsen, T, Finocchiaro, G, Lasorella, A, Rabadan, R, Iavarone, A

Science 2012
23558953 Identification of targetable FGFR gene fusions in diverse cancers

Wu, YM, Su, F, Kalyana-Sundaram, S, Khazanov, N, Ateeq, B, Cao, X, Lonigro, RJ, Vats, P, Wang, R, Lin, SF, Cheng, AJ, Kunju, LP, Siddiqui, J, Tomlins, SA, Wyngaard, P, Sadis, S, Roychowdhury, S, Hussain, MH, Feng, FY, Zalupski, MM, Talpaz, M, Pienta, KJ, Rhodes, DR, Robinson, DR, Chinnaiyan, AM

Cancer Discov 2013
24850843 FGFR1/3 tyrosine kinase fusions define a unique molecular subtype of non-small cell lung cancer

Wang, R, Wang, L, Li, Y, Hu, H, Shen, L, Shen, X, Pan, Y, Ye, T, Zhang, Y, Luo, X, Zhang, Y, Pan, B, Li, B, Li, H, Zhang, J, Pao, W, Ji, H, Sun, Y, Chen, H

Clin. Cancer Res. 2014
24588013 Emergence of FGFR family gene fusions as therapeutic targets in a wide spectrum of solid tumours

Parker, BC, Engels, M, Annala, M, Zhang, W

J. Pathol. 2014
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of Plasma membrane FGFR1 fusion dimers [plasma membrane]
Physical Entity
Activity
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created
Cite Us!