FGFR2 fusions autophosphorylate

Stable Identifier
R-HSA-8853313
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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FGFR2 fusions in cholangiocarcinoma and cancers of the breast, lung and thyroid have been shown to promote anchorage independent growth, cellular proliferation and tumorigenesis. In some cases, such as for FGFR2-AHCYL1 and FGFR2-BICC1 fusions in cholangiocarcinoma, these activities have been shown to depend on the FGFR2 kinase domain, suggesting that the fusions undergo autophosphorylation after oligomerization, as is the case for WT FGFR2. FGFR2 fusions, where tested, also show sensitivity to kinase inhibitors such as PD173074 and pazopanib (Arai et al, 2013; Wu et al, 2013; Seo et al, 2012; reviewed in Parker et al, 2014).

Literature References
PubMed ID Title Journal Year
23558953 Identification of targetable FGFR gene fusions in diverse cancers

Wu, YM, Su, F, Kalyana-Sundaram, S, Khazanov, N, Ateeq, B, Cao, X, Lonigro, RJ, Vats, P, Wang, R, Lin, SF, Cheng, AJ, Kunju, LP, Siddiqui, J, Tomlins, SA, Wyngaard, P, Sadis, S, Roychowdhury, S, Hussain, MH, Feng, FY, Zalupski, MM, Talpaz, M, Pienta, KJ, Rhodes, DR, Robinson, DR, Chinnaiyan, AM

Cancer Discov 2013
22975805 The transcriptional landscape and mutational profile of lung adenocarcinoma

Seo, JS, Ju, YS, Lee, WC, Shin, JY, Lee, JK, Bleazard, T, Lee, J, Jung, YJ, Kim, JO, Shin, JY, Yu, SB, Kim, J, Lee, ER, Kang, CH, Park, IK, Rhee, H, Lee, SH, Kim, JI, Kang, JH, Kim, YT

Genome Res. 2012
24122810 Fibroblast growth factor receptor 2 tyrosine kinase fusions define a unique molecular subtype of cholangiocarcinoma

Arai, Y, Totoki, Y, Hosoda, F, Shirota, T, Hama, N, Nakamura, H, Ojima, H, Furuta, K, Shimada, K, Okusaka, T, Kosuge, T, Shibata, T

Hepatology 2014
24588013 Emergence of FGFR family gene fusions as therapeutic targets in a wide spectrum of solid tumours

Parker, BC, Engels, M, Annala, M, Zhang, W

J. Pathol. 2014
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of FGFR2 fusion dimers [plasma membrane]
Physical Entity
Activity
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created
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