Reactome | GTSE1 binds CDKN1A

GTSE1 binds CDKN1A

Stable Identifier

R-HSA-8852362

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Stabilization of the newly synthesized protein product of the CDKN1A (p21) gene, a CDK inhibitor and a TP53 (p53) transcriptional target, requires binding of CDKN1A to FKBPL (WISp39). FKBPL simultaneously interacts with CDKN1A and a chaperone protein HSP90, forming a ternary complex (Jascur et al. 2005). GTSE1 was identified as another component of the complex of CDKN1A, FKBPL and HSP90. GTSE1 directly interacts with CDKN1A and FKBPL and contributes to CDKN1A stabilization (Bublik et al. 2010). Increased CDKN1A levels delay G2/M onset and rescue cells from G2 checkpoint-induced apoptosis, thus causing resistance to taxol induced cytotoxicity (Yu et al. 1998, Bublik et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
15664193	Regulation of p21(WAF1/CIP1) stability by WISp39, a Hsp90 binding TPR protein Fotedar, R, Brickner, H, Smith, B, Jascur, T, Fotedar, A, El Khissiin, A, Salles-Passador, I, Barbier, V	Mol. Cell	2005
20018861	Human GTSE-1 regulates p21(CIP1/WAF1) stability conferring resistance to paclitaxel treatment Schneider, C, Bublik, DR, Monte, M, Triolo, G, Scolz, M	J. Biol. Chem.	2010
9844631	Overexpression of ErbB2 blocks Taxol-induced apoptosis by upregulation of p21Cip1, which inhibits p34Cdc2 kinase Yao, J, Jing, T, Yu, D, Hung, MC, Tan, M, McDonnell, TJ, Liu, B	Mol. Cell	1998