GTSE1 promotes translocation of TP53 to the cytosol

Stable Identifier
R-HSA-8852351
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
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GTSE1 promotes translocation of TP53 to the cytosol
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Binding of GTSE1 to TP53 (p53) in the nucleus promotes translocation of TP53 to the cytosol. This process is dependent on the nuclear export signal (NES) of GTSE1 (Monte et al. 2004).
Literature References
PubMed ID Title Journal Year
14707141 hGTSE-1 expression stimulates cytoplasmic localization of p53

Del Sal, G, Collavin, L, Schneider, C, Monte, M, Marchionni, L, Benetti, R

J. Biol. Chem. 2004
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Event Information
Go Biological Process
positive regulation of protein export from nucleus (0046827)
Orthologous Events
GTSE1 promotes translocation of TP53 to the cytosol (Bos taurus)
GTSE1 promotes translocation of TP53 to the cytosol (Canis familiaris)
GTSE1 promotes translocation of TP53 to the cytosol (Danio rerio)
GTSE1 promotes translocation of TP53 to the cytosol (Mus musculus)
GTSE1 promotes translocation of TP53 to the cytosol (Rattus norvegicus)
GTSE1 promotes translocation of TP53 to the cytosol (Sus scrofa)
GTSE1 promotes translocation of TP53 to the cytosol (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2016-01-15)
Reviewed
Bird, AW  (2016-01-22)
Created
Orlic-Milacic, M  (2016-01-16)
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