Reactome | Wax and plasmalogen biosynthesis

Wax and plasmalogen biosynthesis

Stable Identifier

R-HSA-8848584

Type

Pathway

Species

Homo sapiens

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Waxes are esters of long chain fatty acids and long chain fatty alcohols that play an important role in protecting the skin surface from drying and abrasion (Cheng & Russell 2004a,b). Plasmalogens are an abundant subclass of phospholipids. While their functions are not well understood, defects in their metabolism are associated with serious human disease (de Vet et al. 1999; Nagan and Zoeller 2001). The biosynthesis of these two classes of molecules both start with the reduction of palmitoyl-CoA (PALM-CoA) to hexadecan-1-ol (HXOL) so it is convenient to group them here.

Literature References

PubMed ID	Title	Journal	Year
15220348	Mammalian wax biosynthesis. I. Identification of two fatty acyl-Coenzyme A reductases with different substrate specificities and tissue distributions Cheng, JB, Russell, DW	J Biol Chem	2004
15220349	Mammalian wax biosynthesis. II. Expression cloning of wax synthase cDNAs encoding a member of the acyltransferase enzyme family Cheng, JB, Russell, DW	J. Biol. Chem.	2004
10553003	Ether lipid biosynthesis: alkyl-dihydroxyacetonephosphate synthase protein deficiency leads to reduced dihydroxyacetonephosphate acyltransferase activities de Vet, EC, IJlst, L, Oostheim, W, Dekker, C, Moser, HW, van den Bosch, H	J Lipid Res	1999
11275267	Plasmalogens: biosynthesis and functions Nagan, N, Zoeller, RA	Prog Lipid Res	2001