Plasmalogen biosynthesis

Stable Identifier
R-HSA-75896
Type
Pathway
Species
Homo sapiens
Compartment
Synonyms
Synthesis of lysophosphatidic acid from dihydroxyacetone phosphate
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser

1-Acylglycerol-3-phosphate is synthesized from dihydroxyacetone phosphate, an acyl CoA molecule and NADPH + H+ in four reactions catalyzed by peroxisomal enzymes, either in the matrix of the organelle or associated with its membrane. These reactions are annotated here for palmityl (C16:0) CoA. In a series of less well-characterized reactions in the cytosol and endoplasmic reticulum, these molecules are converted to ether lipids (plasmalogens). The functions of plasmalogens are not well understood. They are an abundant subclass of phospholipids, however, and defects in their metabolism are associated with serious human disease (de Vet et al. 1999; Nagan and Zoeller 2001).

Literature References
PubMed ID Title Journal Year
11275267 Plasmalogens: biosynthesis and functions

Nagan, N, Zoeller, RA

Prog Lipid Res 2001
10553003 Ether lipid biosynthesis: alkyl-dihydroxyacetonephosphate synthase protein deficiency leads to reduced dihydroxyacetonephosphate acyltransferase activities

de Vet, EC, IJlst, L, Oostheim, W, Dekker, C, Moser, HW, van den Bosch, H

J Lipid Res 1999
Participants
Participant Of
Event Information
Orthologous Events
Authored
Reviewed
Created
Cite Us!