Activated PTK6 (BRK) binds to CDKN1B (p27KIP1) that is in a complex with CDK4 and cyclin D1 (CCND1). Since PTK6 increases cyclin E1 (CCNE1) levels downstream of ERBB2 while decreasing CDKN1B levels, PTK6 probably also associates with CDKN1B bound to the complex of CCNE1 and CDK2 (Xiang et al. 2008).
Wagner, R, Patel, P, Asbach, B, Blain, SW, Coltoff, A, Shteyn, E, Gomez, C, Bhuyan, S, Tyner, AL
Muthuswamy, SK, Xiang, B, Lakshmi, B, Yu, M, Miller, WT, Krasnitz, A, Hicks, J, Qiu, H, Chatti, K
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