Activated PTK6 binds CDKN1B

Stable Identifier
Reaction [binding]
Homo sapiens
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Activated PTK6 (BRK) binds to CDKN1B (p27KIP1) that is in a complex with CDK4 and cyclin D1 (CCND1). Since PTK6 increases cyclin E1 (CCNE1) levels downstream of ERBB2 while decreasing CDKN1B levels, PTK6 probably also associates with CDKN1B bound to the complex of CCNE1 and CDK2 (Xiang et al. 2008).

Literature References
PubMed ID Title Journal Year
18719096 Brk is coamplified with ErbB2 to promote proliferation in breast cancer

Xiang, B, Chatti, K, Qiu, H, Lakshmi, B, Krasnitz, A, Hicks, J, Yu, M, Miller, WT, Muthuswamy, SK

Proc. Natl. Acad. Sci. U.S.A. 2008
25733683 Brk/Protein tyrosine kinase 6 phosphorylates p27KIP1, regulating the activity of cyclin D-cyclin-dependent kinase 4

Patel, P, Asbach, B, Shteyn, E, Gomez, C, Coltoff, A, Bhuyan, S, Tyner, AL, Wagner, R, Blain, SW

Mol. Cell. Biol. 2015
Participant Of
Orthologous Events
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