Reactome | Activated PTK6 binds CDKN1B

Activated PTK6 binds CDKN1B

Stable Identifier

R-HSA-8848414

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - Mitotic G1 phase and G1/S transition (Homo sapiens)
    - G1/S Transition (Homo sapiens)
      - Cyclin E associated events during G1/S transition (Homo sapiens)
        
        SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
        
        Activated PTK6 binds CDKN1B (Homo sapiens)
  - S Phase (Homo sapiens)
    - Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
      - SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
        
        Activated PTK6 binds CDKN1B (Homo sapiens)

General

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Activated PTK6 (BRK) binds to CDKN1B (p27KIP1) that is in a complex with CDK4 and cyclin D1 (CCND1). Since PTK6 increases cyclin E1 (CCNE1) levels downstream of ERBB2 while decreasing CDKN1B levels, PTK6 probably also associates with CDKN1B bound to the complex of CCNE1 and CDK2 (Xiang et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
25733683	Brk/Protein tyrosine kinase 6 phosphorylates p27KIP1, regulating the activity of cyclin D-cyclin-dependent kinase 4 Wagner, R, Patel, P, Asbach, B, Blain, SW, Coltoff, A, Shteyn, E, Gomez, C, Bhuyan, S, Tyner, AL	Mol. Cell. Biol.	2015
18719096	Brk is coamplified with ErbB2 to promote proliferation in breast cancer Muthuswamy, SK, Xiang, B, Lakshmi, B, Yu, M, Miller, WT, Krasnitz, A, Hicks, J, Qiu, H, Chatti, K	Proc. Natl. Acad. Sci. U.S.A.	2008