PTK6 Regulates Cell Cycle

Stable Identifier
R-HSA-8849470
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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PTK6 Regulates Cell Cycle
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PTK6 promotes cell cycle progression by phosphorylating and inactivating CDK inhibitor CDKN1B (p27) (Patel et al. 2015). PTK6 also negatively modulates CDKN1B expression via regulation of the activity of the FOXO3 (FOXO3A) transcription factor (Chan and Nimnual 2010).
Literature References
PubMed ID Title Journal Year
25733683 Brk/Protein tyrosine kinase 6 phosphorylates p27KIP1, regulating the activity of cyclin D-cyclin-dependent kinase 4

Patel, P, Asbach, B, Shteyn, E, Gomez, C, Coltoff, A, Bhuyan, S, Tyner, AL, Wagner, R, Blain, SW

Mol. Cell. Biol. 2015
20162673 Deregulation of the cell cycle by breast tumor kinase (Brk)

Chan, E, Nimnual, AS

Int. J. Cancer 2010
Participants
Events
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as an event of
Event Information
Go Biological Process
positive regulation of cell cycle (0045787)
Orthologous Events
PTK6 Regulates Cell Cycle (Bos taurus)
PTK6 Regulates Cell Cycle (Caenorhabditis elegans)
PTK6 Regulates Cell Cycle (Danio rerio)
PTK6 Regulates Cell Cycle (Mus musculus)
PTK6 Regulates Cell Cycle (Rattus norvegicus)
PTK6 Regulates Cell Cycle (Sus scrofa)
PTK6 Regulates Cell Cycle (Xenopus tropicalis)
Cross References
BioModels Database
Authored
Orlic-Milacic, M  (2016-01-05)
Reviewed
Pires, IM  (2016-02-07)
Created
Orlic-Milacic, M  (2015-12-16)
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