IL18BP binds IL18

Stable Identifier
R-HSA-8848392
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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IL18BP binds IL18
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Interleukin-18 binding protein (IL18BP) is a constitutively secreted protein, with an exceptionally high affinity for IL18 (400 pM) (Kim et al. 2000). It is present in the serum of healthy humans at a 20-fold molar excess compared to IL18 (Novick et al. 2001) and may blunt the Th1 response to foreign organisms, thereby reducing any autoimmune responses to a routine infection (Dinarello et al. 2013). Some studies indicate this IL18BP:IL18 complex negatively regulates IL18:IL18 receptor interaction (Kim et al. 2002, Im et al. 2002).
Literature References
PubMed ID Title Journal Year
10023777 Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response

Kim, SH, Dinarello, CA, Reznikov, LL, Rubinstein, M, Novick, D, Fantuzzi, G

Immunity 1999
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Orthologous Events
IL18BP binds IL18 (Bos taurus)
IL18BP binds IL18 (Mus musculus)
IL18BP binds IL18 (Rattus norvegicus)
IL18BP binds IL18 (Sus scrofa)
Authored
Jupe, S  (2014-06-04)
Reviewed
Meldal, BH  (2016-01-28)
Created
Jupe, S  (2015-12-08)
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