ERBB2 promotes PTK6 autophosphorylation

Stable Identifier
R-HSA-8848005
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Binding of PTK6 (BRK) to activated ERBB2 receptor stimulates autophosphorylation of PTK6 on tyrosine residue Y342 (Xiang et al. 2008, Peng et al. 2015). Autophosphorylation at Y342 significantly increases catalytic activity of PTK6 (Qiu and Miller 2002).

Literature References
PubMed ID Title Journal Year
18719096 Brk is coamplified with ErbB2 to promote proliferation in breast cancer

Xiang, B, Chatti, K, Qiu, H, Lakshmi, B, Krasnitz, A, Hicks, J, Yu, M, Miller, WT, Muthuswamy, SK

Proc. Natl. Acad. Sci. U.S.A. 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of p-ERBB2 heterodimers:PTK6 [plasma membrane]
Physical Entity
Activity
Orthologous Events
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Reviewed
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