ERBB2 Activates PTK6 Signaling

Stable Identifier
R-HSA-8847993
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
ERBB2 Activates PTK6 Signaling
Click the image above or here to open this pathway in the Pathway Browser

PTK6 (BRK) is activated downstream of ERBB2 (HER) (Xiang et al. 2008, Peng et al. 2015) and other receptor tyrosine kinases, such as EGFR (Kamalati et al. 1996) and MET (Castro and Lange 2010). However, it is not clear if MET and EGFR activate PTK6 directly or act through ERBB2, since it is known that ERBB2 forms heterodimers with EGFR (Spivak-Kroizman et al. 1992), and MET can heterodimerize with both EGFR and ERBB2 (Tanizaki et al. 2011).

Literature References
PubMed ID Title Journal Year
26247733 Protein tyrosine kinase 6 promotes ERBB2-induced mammary gland tumorigenesis in the mouse

Peng, M, Ball-Kell, SM, Tyner, AL

Cell Death Dis 2015
20687930 Breast tumor kinase and extracellular signal-regulated kinase 5 mediate Met receptor signaling to cell migration in breast cancer cells

Castro, NE, Lange, CA

Breast Cancer Res. 2010
21847121 Differential roles of trans-phosphorylated EGFR, HER2, HER3, and RET as heterodimerisation partners of MET in lung cancer with MET amplification

Tanizaki, J, Okamoto, I, Sakai, K, Nakagawa, K

Br. J. Cancer 2011
8940083 Brk, a breast tumor-derived non-receptor protein-tyrosine kinase, sensitizes mammary epithelial cells to epidermal growth factor

Kamalati, T, Jolin, HE, Mitchell, PJ, Barker, KT, Jackson, LE, Dean, CJ, Page, MJ, Gusterson, BA, Crompton, MR

J. Biol. Chem. 1996
18719096 Brk is coamplified with ErbB2 to promote proliferation in breast cancer

Xiang, B, Chatti, K, Qiu, H, Lakshmi, B, Krasnitz, A, Hicks, J, Yu, M, Miller, WT, Muthuswamy, SK

Proc. Natl. Acad. Sci. U.S.A. 2008
1349015 Heterodimerization of c-erbB2 with different epidermal growth factor receptor mutants elicits stimulatory or inhibitory responses

Spivak-Kroizman, T, Rotin, D, Pinchasi, D, Ullrich, A, Schlessinger, J, Lax, I

J. Biol. Chem. 1992
Participants
Events
Participant Of
hasEvent
Orthologous Events
ERBB2 Activates PTK6 Signaling (Bos taurus)
ERBB2 Activates PTK6 Signaling (Caenorhabditis elegans)
ERBB2 Activates PTK6 Signaling (Danio rerio)
ERBB2 Activates PTK6 Signaling (Mus musculus)
ERBB2 Activates PTK6 Signaling (Rattus norvegicus)
ERBB2 Activates PTK6 Signaling (Sus scrofa)
ERBB2 Activates PTK6 Signaling (Xenopus tropicalis)
Cross References
BioModels Database
Authored
Orlic-Milacic, M  (2016-01-05)
Reviewed
Pires, IM  (2016-02-07)
Created
Orlic-Milacic, M  (2015-12-04)