ERBB2 Activates PTK6 Signaling

Stable Identifier
Homo sapiens
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PTK6 (BRK) is activated downstream of ERBB2 (HER) (Xiang et al. 2008, Peng et al. 2015) and other receptor tyrosine kinases, such as EGFR (Kamalati et al. 1996) and MET (Castro and Lange 2010). However, it is not clear if MET and EGFR activate PTK6 directly or act through ERBB2, since it is known that ERBB2 forms heterodimers with EGFR (Spivak-Kroizman et al. 1992), and MET can heterodimerize with both EGFR and ERBB2 (Tanizaki et al. 2011).

Literature References
PubMed ID Title Journal Year
20687930 Breast tumor kinase and extracellular signal-regulated kinase 5 mediate Met receptor signaling to cell migration in breast cancer cells

Lange, CA, Castro, NE

Breast Cancer Res. 2010
26247733 Protein tyrosine kinase 6 promotes ERBB2-induced mammary gland tumorigenesis in the mouse

Peng, M, Tyner, AL, Ball-Kell, SM

Cell Death Dis 2015
21847121 Differential roles of trans-phosphorylated EGFR, HER2, HER3, and RET as heterodimerisation partners of MET in lung cancer with MET amplification

Nakagawa, K, Tanizaki, J, Okamoto, I, Sakai, K

Br. J. Cancer 2011
8940083 Brk, a breast tumor-derived non-receptor protein-tyrosine kinase, sensitizes mammary epithelial cells to epidermal growth factor

Gusterson, BA, Jackson, LE, Crompton, MR, Kamalati, T, Jolin, HE, Dean, CJ, Page, MJ, Barker, KT, Mitchell, PJ

J. Biol. Chem. 1996
18719096 Brk is coamplified with ErbB2 to promote proliferation in breast cancer

Muthuswamy, SK, Xiang, B, Lakshmi, B, Yu, M, Miller, WT, Krasnitz, A, Hicks, J, Qiu, H, Chatti, K

Proc. Natl. Acad. Sci. U.S.A. 2008
1349015 Heterodimerization of c-erbB2 with different epidermal growth factor receptor mutants elicits stimulatory or inhibitory responses

Schlessinger, J, Pinchasi, D, Rotin, D, Lax, I, Ullrich, A, Spivak-Kroizman, T

J. Biol. Chem. 1992
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