2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde

Stable Identifier
R-HSA-880033
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
ReviewStatus
5/5
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2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde
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ADHFE1 catalyzes the reversible reaction of 2-oxoglutarate and 4-hydroxybutyrate to form (R)-2-hydroxyglutarate and succinate semialdehyde (Struys et al. 2005). The localization of human ADHFE1 to the mitochondrial matrix is inferred from the location determined experimentally for its rat homolog (Kaufman et al. 1988).
Literature References
PubMed ID Title Journal Year
16435184 Kinetic characterization of human hydroxyacid-oxoacid transhydrogenase: relevance to D-2-hydroxyglutaric and gamma-hydroxybutyric acidurias

Struys, EA, Verhoeven, NM, Ten Brink, HJ, Wickenhagen, WV, Gibson, KM, Jakobs, C

J Inherit Metab Dis 2005
3182820 Isolation and characterization of a hydroxyacid-oxoacid transhydrogenase from rat kidney mitochondria

Kaufman, EE, Nelson, T, Fales, HM, Levin, DM

J Biol Chem 1988
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Output
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as an event of
Catalyst Activity

hydroxyacid-oxoacid transhydrogenase activity of ADHFE1(1-?) [mitochondrial matrix]

Physical Entity
ADHFE1(1-?) [mitochondrial matrix] (Homo sapiens)
Activity
hydroxyacid-oxoacid transhydrogenase activity (GO:0047988)
Orthologous Events
2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Bos taurus)
2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Caenorhabditis elegans)
2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Canis familiaris)
2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Danio rerio)
2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Dictyostelium discoideum)
2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Drosophila melanogaster)
2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Gallus gallus)
2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Mus musculus)
2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Rattus norvegicus)
2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Sus scrofa)
Cross References
RHEA
Authored
D'Eustachio, P  (2010-06-26)
Reviewed
Jassal, B  (2010-11-09)
Rush, MG  (2011-01-31)
Created
D'Eustachio, P  (2010-06-26)
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