Reactome | Recruitment of SHC1 is mediated by Y593 of the common beta chain

Recruitment of SHC1 is mediated by Y593 of the common beta chain

Stable Identifier

R-HSA-879934

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Recruitment of SHC1 is mediated by Y593 of the common beta chain

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Upon receptor activation, Shc is recruited to the receptor complex, where it becomes tyrosine phosphorylated. The recruitment of Shc is mediated by Y593 (Y577 in the mature peptide) of the common beta chain (Bc), which binds the PTB domain of Shc (Pratt et al. 1996). Phosphorylated Shc interacts with Grb2 within a Grb2:Gab2 complex, promoting tyrosine phosphorylation of Gab2. The p85 subunit of PI3Kinases associates with phosphorylated Gab, and this induces activation of the catalytic p110 PI3K subunit leading to activation of Akt kinase, thereby regulating cell survival and/or proliferation.

Literature References

PubMed ID	Title	Journal	Year
8647804	Evidence for a physical association between the Shc-PTB domain and the beta c chain of the granulocyte-macrophage colony-stimulating factor receptor Pratt, JC, Weiss, M, Sieff, CA, Shoelson, SE, Burakoff, SJ, Ravichandran, KS	J Biol Chem	1996
10982827	New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway Gu, H, Maeda, H, Moon, JJ, Lord, JD, Yoakim, M, Nelson, BH, Neel, BG	Mol Cell Biol	2000