Recruitment of SHC1 is mediated by Y593 of the common beta chain

Stable Identifier
R-HSA-879934
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Upon receptor activation, Shc is recruited to the receptor complex, where it becomes tyrosine phosphorylated. The recruitment of Shc is mediated by Y593 (Y577 in the mature peptide) of the common beta chain (Bc), which binds the PTB domain of Shc (Pratt et al. 1996). Phosphorylated Shc interacts with Grb2 within a Grb2:Gab2 complex, promoting tyrosine phosphorylation of Gab2. The p85 subunit of PI3Kinases associates with phosphorylated Gab, and this induces activation of the catalytic p110 PI3K subunit leading to activation of Akt kinase, thereby regulating cell survival and/or proliferation.

Literature References
PubMed ID Title Journal Year
10982827 New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway

Gu, H, Maeda, H, Moon, JJ, Lord, JD, Yoakim, M, Nelson, BH, Neel, BG

Mol Cell Biol 2000
8647804 Evidence for a physical association between the Shc-PTB domain and the beta c chain of the granulocyte-macrophage colony-stimulating factor receptor

Pratt, JC, Weiss, M, Sieff, CA, Shoelson, SE, Burakoff, SJ, Ravichandran, KS

J Biol Chem 1996
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