Reactome | CD97 binds CD55

CD97 binds CD55

Stable Identifier

R-HSA-879674

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

ReviewStatus

5/5

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CD55 (or Decay Accelerating Factor; DAF) is a member of the regulators of complement activation (RCA) family. It protects host cells from complement system attack by binding to C3b and C4b preventing formation of the membrane attack complex. CD97 is a member of the Adhesion class or LNB subfamily of family B GPCRs, characterized by long N-terminal regions containing domains contain multiple tandem epidermal growth factor (EGF)-like repeats in their N-termini (Foord et al. 2002). CD97 is constitutively expressed on granulocytes and monocytes and is rapidly up-regulated on activated T and B cells. It is known to have many splice forms containing different numbers of EGF domains, consequently binding CD55 with differing affinities. The highest affinity variant has three EGF domains. The leukocyte-restricted expression pattern of CD97, and the presence of both CD97 and CD55 in arthritic joints suggest a possible role in adhesion and signaling within the inflammatory and immune responses (Lin et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
9064337	The seven-span transmembrane receptor CD97 has a cellular ligand (CD55, DAF) Hamann, J, van Schijndel, GM, Vogel, B, van Lier, RA	J Exp Med	1996
11297558	Molecular analysis of the epidermal growth factor-like short consensus repeat domain-mediated protein-protein interactions: dissection of the CD97-CD55 complex Knott, V, Evans, D, Chaudhry, Y, Gordon, S, Stacey, M, Lea, S, Saxby, C, Handford, PA, Lin, HH, McKnight, AJ	J Biol Chem	2001