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IPAF is activated
Stable Identifier
R-HSA-874084
Type
Reaction [omitted]
Species
Homo sapiens
Related Species
Salmonella typhimurium
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Homo sapiens)
Inflammasomes (Homo sapiens)
The IPAF inflammasome (Homo sapiens)
IPAF is activated (Homo sapiens)
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Although a direct interaction between IPAF and an activating ligand has not been demonstrated, IPAF can be activated by cytosolic flagellin either applied experimentally or resulting from the activity of the virulence-associated type III or V secretion systems (Franchi et al. 2006, Miao et al 2007, 2008). Activation can also be flagellin-independent (Suzuki et al. 2007, Sutterwala et al. 2007), suggesting alternative mechanisms that are likely to involve recognition of components of the bacterial type III secretion system (Miao et al. 2010). The LRR domain of IPAF appears to repress activity in the absence of a ligand as removal of this domain leads to constitutive activation (Poyet et al. 2001).
Participants
Input
IPAF elicitors [cytosol]
(Salmonella typhimurium)
NLRC4 [cytosol]
(Homo sapiens)
Output
IPAF elicitors:NLRC4 [cytosol]
(Homo sapiens)
Participates
as an event of
The IPAF inflammasome (Homo sapiens)
Inferred From
Ipaf is activated (Mus musculus)
Authored
Jupe, S (2010-04-22)
Reviewed
Kufer, TA (2011-04-28)
Rittinger, K (2011-06-06)
Wong, E (2011-06-06)
Created
Jupe, S (2010-06-10)
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