Ipaf is activated

Stable Identifier
Reaction [omitted]
Mus musculus
SVG |   | PPTX  | SBGN
Ipaf is activated

Although a direct interaction between IPAF and an activating ligand has not been demonstrated, IPAF can be activated by cytosolic flagellin either applied experimentally or resulting from the activity of the virulence-associated type III or V secretion systems (Franchi et al. 2006, Miao et al 2007, 2008). Activation can also be flagellin-independent (Suzuki et al. 2007, Sutterwala et al. 2007), suggesting alternative mechanisms that are likely to involve recognition of components of the bacterial type III secretion system (Miao et al. 2010). The LRR domain of IPAF appears to repress activity in the absence of a ligand as removal of this domain leads to constitutive activation (Poyet et al. 2001).

Literature References
PubMed ID Title Journal Year
16984919 Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf

Kanneganti, TD, Ozören, N, Franchi, L, Brady, G, Nunez, G, Akira, S, Body-Malapel, M, Jagirdar, R, Meshinchi, S, Gewirtz, A, Amer, A

J Biol Chem 2006
15190255 Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

Dixit, VM, Vucic, D, Erickson, S, Newton, K, Mariathasan, S, Roose-Girma, M, Lee, WP, Monack, DM, French, DM

Nature 2004
17690885 TLR5 and Ipaf: dual sensors of bacterial flagellin in the innate immune system

Warren, SE, Andersen-Nissen, E, Aderem, A, Miao, EA

Semin Immunopathol 2007
17935074 Critical role for Ipaf in Pseudomonas aeruginosa-induced caspase-1 activation

Kanneganti, TD, Franchi, L, Ramphal, R, Stoolman, J, Nunez, G, Verma, A

Eur J Immunol 2007
Orthologous Events
Cite Us!