NLRP1 senses MDP

Stable Identifier
R-HSA-844447
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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NLRP1 senses MDP
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In vitro studies using purified NLRP1 and caspase-1 suggest that MDP induces a conformational change in NLRP1 that allows it to bind nucleotides and oligomerize, creating a binding platform for caspase-1 (Faustin et al. 2008). There is no direct evidence that NLRP1 binds MDP so the mechanism that stimulates NLRP1 is unclear.
Literature References
PubMed ID Title Journal Year
17349957 Reconstituted NALP1 inflammasome reveals two-step mechanism of caspase-1 activation

Faustin, B, Lartigue, L, Bruey, JM, Luciano, F, Sergienko, E, Bailly-Maitre, B, Volkmann, N, Hanein, D, Rouiller, I, Reed, JC

Mol Cell 2007
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Orthologous Events
NLRP1 senses MDP (Bos taurus)
NLRP1 senses MDP (Canis familiaris)
NLRP1 senses MDP (Danio rerio)
NLRP1 senses MDP (Gallus gallus)
NLRP1 senses MDP (Mus musculus)
NLRP1 senses MDP (Rattus norvegicus)
Authored
Jupe, S  (2010-04-22)
Reviewed
Kufer, TA  (2011-04-28)
Rittinger, K  (2011-06-06)
Wong, E  (2011-06-06)
Created
Jupe, S  (2010-05-28)
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