Deamination at C6 position of adenosine in Editosome (ADAR2)

Stable Identifier
R-HSA-77615
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
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At the beginning of this reaction, 1 molecule of 'H2O', and 1 molecule of 'Editosome (ADAR2) complex' are present. At the end of this reaction, 1 molecule of 'NH3', and 1 molecule of 'A to I edited RNA:Editosome (ADAR2) complex' are present.

This reaction takes place in the 'nucleus' and is mediated by the 'double-stranded RNA adenosine deaminase activity' of 'ADAR2 homodimer' (Zheng et al.2017).

Literature References
PubMed ID Title Journal Year
28132026 DNA editing in DNA/RNA hybrids by adenosine deaminases that act on RNA

Zheng, Y, Lorenzo, C, Beal, PA

Nucleic Acids Res. 2017
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
double-stranded RNA adenosine deaminase activity of ADAR2 homodimer [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Created