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C6 deamination of adenosine
Stable Identifier
R-HSA-75102
Type
Pathway
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Metabolism of RNA (Homo sapiens)
mRNA Editing (Homo sapiens)
mRNA Editing: A to I Conversion (Homo sapiens)
C6 deamination of adenosine (Homo sapiens)
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Hydrolytic deamination of adenosine leads to inosine. Ammonia is presumed to be released during this reaction.
Literature References
PubMed ID
Title
Journal
Year
9111310
Editing of glutamate receptor B subunit ion channel RNAs by four alternatively spliced DRADA2 double-stranded RNA adenosine deaminases.
Nishikura, K
,
Carter, KC
,
Lai, F
,
Chen, CX
Mol Cell Biol
1997
7565688
Expression and regulation by interferon of a double-stranded-RNA-specific adenosine deaminase from human cells: evidence for two forms of the deaminase.
Samuel, CE
,
Patterson, JB
Mol Cell Biol
1995
Participants
Events
Deamination at C6 position of adenosine in Editosome (ADAR1)
(Homo sapiens)
Deamination at C6 position of adenosine in Editosome (ADAR2)
(Homo sapiens)
Participates
as an event of
mRNA Editing: A to I Conversion (Homo sapiens)
Orthologous Events
C6 deamination of adenosine (Bos taurus)
C6 deamination of adenosine (Caenorhabditis elegans)
C6 deamination of adenosine (Canis familiaris)
C6 deamination of adenosine (Drosophila melanogaster)
C6 deamination of adenosine (Gallus gallus)
C6 deamination of adenosine (Mus musculus)
C6 deamination of adenosine (Rattus norvegicus)
C6 deamination of adenosine (Sus scrofa)
C6 deamination of adenosine (Xenopus tropicalis)
Authored
Gopinathrao, G (2003-12-05)
Created
Carmichael, GG (2003-08-22)
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