Formation of dsRNA structure by looping

Stable Identifier
Reaction [transition]
Homo sapiens
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Site-specific A to I conversion requires dsRNA structures present around the editing site. These structures can be formed by exonic sequences and neighboring intronic sequences. An editing-site complementary sequence (ECS) has been identified in mice (Gerber e al.2001, Dawson et al.2004 ). Although minimal requirements for A to I editing have been identified, detailed mechanisms describing the individual steps are not yet well studied in humans.

Literature References
PubMed ID Title Journal Year
14660658 Structure and sequence determinants required for the RNA editing of ADAR2 substrates

Dawson, TR, Sansam, CL, Emeson, RB

J. Biol. Chem. 2004
11406411 RNA editing by base deamination: more enzymes, more targets, new mysteries.

Gerber, AP, Keller, W

Trends Biochem Sci 2001
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