Reactome | trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA

trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA

Stable Identifier

R-HSA-77301

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

Locations in the PathwayBrowser

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Metabolism (Homo sapiens)

- Metabolism of lipids (Homo sapiens)
  - Fatty acid metabolism (Homo sapiens)
    - Mitochondrial Fatty Acid Beta-Oxidation (Homo sapiens)
      - mitochondrial fatty acid beta-oxidation of saturated fatty acids (Homo sapiens)
        
        Beta oxidation of palmitoyl-CoA to myristoyl-CoA (Homo sapiens)
        
        trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Homo sapiens)

General

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trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA

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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

At the beginning of this reaction, 1 molecule of 'H2O', and 1 molecule of 'trans-Hexadec-2-enoyl-CoA' are present. At the end of this reaction, 1 molecule of '(S)-3-Hydroxyhexadecanoyl-CoA' is present.

This reaction takes place in the 'mitochondrial matrix' and is mediated by the 'enoyl-CoA hydratase activity' of 'Trifunctional Protein'.

Literature References

PubMed ID	Title	Journal	Year
1550553	Human liver long-chain 3-hydroxyacyl-coenzyme A dehydrogenase is a multifunctional membrane-bound beta-oxidation enzyme of mitochondria. Middleton, B, Carpenter, K, Pollitt, RJ	Biochem Biophys Res Commun	1992