Reactome | Ethylene is oxidized to Ethylene oxide by CYP1A1

Ethylene is oxidized to Ethylene oxide by CYP1A1

Stable Identifier

R-HSA-76472

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, endoplasmic reticulum lumen, smooth endoplasmic reticulum

Synonyms

Ethylene oxidized to Ethylene oxide

ReviewStatus

5/5

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Ethylene is oxidized to Ethylene oxide by CYP1A1

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A simple example of epoxidation is the oxidation of an alkene (olefin) to the epoxide (oxirane), catalysed by CYP1A1. Even the simplest of epoxides (ethylene oxide) can react with DNA and amino groups in a protein.

Literature References

PubMed ID	Title	Journal	Year
7217086	Destruction of cytochrome P-450 by ethylene. Structure of the resulting prosthetic heme adduct. Kunze, KL, Beilan, HS, Mico, BA, Ortiz, de Montell	J Biol Chem	1981
12464245	Cytochrome P450 oxidations in the generation of reactive electrophiles: epoxidation and related reactions Guengerich, FP	Arch Biochem Biophys	2003