O-atom dealkylation of dextromethorphan

Stable Identifier
R-HSA-76456
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, endoplasmic reticulum lumen, smooth endoplasmic reticulum
ReviewStatus
5/5
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O-atom dealkylation of dextromethorphan
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
At the beginning of this reaction, 1 molecule of 'H+', 1 molecule of 'Dextromethorphan', 1 molecule of 'Oxygen', and 1 molecule of 'NADPH' are present. At the end of this reaction, 1 molecule of 'NADP+', 1 molecule of 'Dextrorphan', 1 molecule of 'Formaldehyde', and 1 molecule of 'H2O' are present.

This reaction takes place in the 'smooth endoplasmic reticulum' and is mediated by the 'oxygen binding activity' of 'Cytochrome P450 2D6 '.
Literature References
PubMed ID Title Journal Year
  Casarett and Doull's Toxicology 5th Edn

Parkinson, A

  1995
Participants
Input
Output
Participates
as an event of
Catalyst Activity

monooxygenase activity of Cytochrome P450 (CYP2D6 based) [endoplasmic reticulum membrane]

Physical Entity
Cytochrome P450 (CYP2D6 based) [endoplasmic reticulum membrane] (Homo sapiens)
Activity
monooxygenase activity (GO:0004497)
Orthologous Events
O-atom dealkylation of dextromethorphan (Bos taurus)
O-atom dealkylation of dextromethorphan (Caenorhabditis elegans)
O-atom dealkylation of dextromethorphan (Canis familiaris)
O-atom dealkylation of dextromethorphan (Danio rerio)
O-atom dealkylation of dextromethorphan (Dictyostelium discoideum)
O-atom dealkylation of dextromethorphan (Drosophila melanogaster)
O-atom dealkylation of dextromethorphan (Gallus gallus)
O-atom dealkylation of dextromethorphan (Mus musculus)
O-atom dealkylation of dextromethorphan (Rattus norvegicus)
O-atom dealkylation of dextromethorphan (Sus scrofa)
O-atom dealkylation of dextromethorphan (Xenopus tropicalis)
Created
Jassal, B  (2003-08-05)
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