O-atom dealkylation of dextromethorphan

Stable Identifier
R-HSA-76456
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, endoplasmic reticulum lumen, smooth endoplasmic reticulum
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O-atom dealkylation of dextromethorphan
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

At the beginning of this reaction, 1 molecule of 'H+', 1 molecule of 'Dextromethorphan', 1 molecule of 'Oxygen', and 1 molecule of 'NADPH' are present. At the end of this reaction, 1 molecule of 'NADP+', 1 molecule of 'Dextrorphan', 1 molecule of 'Formaldehyde', and 1 molecule of 'H2O' are present.

This reaction takes place in the 'smooth endoplasmic reticulum' and is mediated by the 'oxygen binding activity' of 'Cytochrome P450 2D6 '.

Literature References
PubMed ID Title Journal Year
  Casarett and Doull's Toxicology 5th Edn

Parkinson, A

  1995
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
monooxygenase activity of Cytochrome P450 (CYP2D6 based) [endoplasmic reticulum membrane]
Physical Entity
Cytochrome P450 (CYP2D6 based) [endoplasmic reticulum membrane]
Activity
monooxygenase activity (0004497)
Orthologous Events
O-atom dealkylation of dextromethorphan (Bos taurus)
O-atom dealkylation of dextromethorphan (Caenorhabditis elegans)
O-atom dealkylation of dextromethorphan (Danio rerio)
O-atom dealkylation of dextromethorphan (Dictyostelium discoideum)
O-atom dealkylation of dextromethorphan (Gallus gallus)
O-atom dealkylation of dextromethorphan (Mus musculus)
O-atom dealkylation of dextromethorphan (Rattus norvegicus)
O-atom dealkylation of dextromethorphan (Xenopus tropicalis)
Created
Jassal, B  (2003-08-05)
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