Dehalogenation of carbon tetrachloride to form a free radical

Stable Identifier
R-HSA-76434
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Dehalogenation of the haloalkane CCl4 to form CCl3. free radical
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Carbon tetrachloride (CCl4) has been widely used as a dry-cleaning agent, in fire extinguishers and in the manufacture of other halogenated hydrocarbons. At toxic doses, CCl4 exposure can damage the liver and kidneys. This toxicity results from CYP2E1-dependant reduction of CCl4 to the reactive trichloromethyl radical (CCl3.).

Literature References
PubMed ID Title Journal Year
10731522 Cytochrome P450 2E1 is the primary enzyme responsible for low-dose carbon tetrachloride metabolism in human liver microsomes

Zangar, RC, Benson, JM, Burnett, VL, Springer, DL

Chem Biol Interact 2000
Participants
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Event Information
Catalyst Activity
Catalyst Activity
Title
monooxygenase activity of Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane]
Physical Entity
Activity
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