Reactome | Dehalogenation of carbon tetrachloride to form a free radical

Dehalogenation of carbon tetrachloride to form a free radical

Stable Identifier

R-HSA-76434

Type

Reaction [transition]

Species

Homo sapiens

Compartment

smooth endoplasmic reticulum

Synonyms

Dehalogenation of the haloalkane CCl4 to form CCl3. free radical

ReviewStatus

5/5

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Metabolism (Homo sapiens)

- Biological oxidations (Homo sapiens)
  - Phase I - Functionalization of compounds (Homo sapiens)
    - Cytochrome P450 - arranged by substrate type (Homo sapiens)
      - Xenobiotics (Homo sapiens)
        
        CYP2E1 reactions (Homo sapiens)
        
        Dehalogenation of carbon tetrachloride to form a free radical (Homo sapiens)

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Dehalogenation of carbon tetrachloride to form a free radical

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Carbon tetrachloride (CCl4) has been widely used as a dry-cleaning agent, in fire extinguishers and in the manufacture of other halogenated hydrocarbons. At toxic doses, CCl4 exposure can damage the liver and kidneys. This toxicity results from CYP2E1-dependant reduction of CCl4 to the reactive trichloromethyl radical (CCl3.).

Literature References

PubMed ID	Title	Journal	Year
10731522	Cytochrome P450 2E1 is the primary enzyme responsible for low-dose carbon tetrachloride metabolism in human liver microsomes Zangar, RC, Benson, JM, Burnett, VL, Springer, DL	Chem Biol Interact	2000