The type 1 promoters recruit TFIIIA, the founding member of the C2H2 zinc finger family of DNA-binding proteins (Engelke et al., 1980; Sakonju et al., 1981). The binding of TFIIIA then allows the binding of TFIIC (Lassar et al., 1983), a complex consisting of five subunits (which differs from the six subunits in S. cerevisiae) in human cells and S. pombe. Once the DNA/TFIIIA/TFIIIC complex is formed, Brf1-TFIIIB joins the complex and this in turn allows the recruitment of RNA polymerase III (Bieker et al., 1985; Setzer and Brown, 1985).
Bieker, JJ, Martin, PL, Roeder, RG
Setzer, DR, Brown, DD
Lassar, AB, Martin, PL, Roeder, RG
Sakonju, S, Brown, DD, Engelke, D, Ng, SY, Shastry, BS, Roeder, RG
Engelke, DR, Ng, SY, Shastry, BS, Roeder, RG
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