palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH

Stable Identifier
R-HSA-75879
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Peroxisomal glyceronephosphate O-acyltransferase (GNPAT) catalyzes the reaction of palmitoyl-CoA and DHAP to form 1-palmitoyl glycerone phosphate (1-palmitoyl dihydroxyacetone phosphate) and CoASH. The active form of the enzyme is one subunit of a heterotrimer with two molecules of the alkylglycerone phosphate synthase (AGPS) enzyme (Biermann et al. 1999). It was first purified and characterized biochemically by Ofman and Wanders (1994). Mutations in the GNPAT gene are associated with rhizomelic chondrodysplasia type 2 (Ofman et al. 1998, 2001).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
glycerone-phosphate O-acyltransferase activity of GNPAT:AGPS complex [peroxisomal matrix]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created