atROL binds RBP1 to form RBP1:atROL

Stable Identifier
R-HSA-74843
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
Before esterification, retinol binds to RBP1 in RPE
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Once all-trans-retinol (atROL) enters the retinal pigment epithelium (RPE) and before esterification takes place, atROL binds to cellular retinol-binding protein 1 (RBP1) (Folli et al. 2001). The resultant complex (RBP1:atROL) serves as a substrate for lecithin retinol acyltransferase (LRAT), the main enzyme responsible for the esterification of atROL.

Literature References
PubMed ID Title Journal Year
11274389 Identification, retinoid binding, and x-ray analysis of a human retinol-binding protein

Folli, C, Calderone, V, Ottonello, S, Bolchi, A, Zanotti, G, Stoppini, M, Berni, R

Proc. Natl. Acad. Sci. U.S.A. 2001
Participants
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Orthologous Events
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