Release of tyrosine-phosphorylated SHC from the insulin receptor triggers a cascade of signalling events via SOS, RAF and the MAP kinases (Sasaoka et al. 1996, Kleiman et al.2011). This is a black box event since this dissociation is inferred from other reaction which show association and dissociation for this protein under EGF stimulation (Kleiman et al. 2011).
Sorger, PK, Kleiman, LB, Maiwald, T, Conzelmann, H, Lauffenburger, DA
Imamura, T, Sawa, T, Sasaoka, T, Usui, I, Takata, Y, Ishihara, H, Kobayashi, M, Morioka, H, Ishiki, M
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