Dissociation of p-Y427-SHC1 from insulin receptor

Stable Identifier
R-HSA-74743
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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Dissociation of p-Y427-SHC1 from insulin receptor
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Release of tyrosine-phosphorylated SHC from the insulin receptor triggers a cascade of signalling events via SOS, RAF and the MAP kinases (Sasaoka et al. 1996, Kleiman et al.2011). This is a black box event since this dissociation is inferred from other reaction which show association and dissociation for this protein under EGF stimulation (Kleiman et al. 2011).
Literature References
PubMed ID Title Journal Year
21884975 Rapid phospho-turnover by receptor tyrosine kinases impacts downstream signaling and drug binding

Kleiman, LB, Maiwald, T, Conzelmann, H, Lauffenburger, DA, Sorger, PK

Mol. Cell 2011
8702728 Functional importance of amino-terminal domain of Shc for interaction with insulin and epidermal growth factor receptors in phosphorylation-independent manner

Sasaoka, T, Ishihara, H, Sawa, T, Ishiki, M, Morioka, H, Imamura, T, Usui, I, Takata, Y, Kobayashi, M

J. Biol. Chem. 1996
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Orthologous Events
Dissociation of p-Y427-SHC1 from insulin receptor (Bos taurus)
Dissociation of p-Y427-SHC1 from insulin receptor (Canis familiaris)
Dissociation of p-Y427-SHC1 from insulin receptor (Gallus gallus)
Dissociation of p-Y427-SHC1 from insulin receptor (Mus musculus)
Dissociation of p-Y427-SHC1 from insulin receptor (Rattus norvegicus)
Dissociation of p-Y427-SHC1 from insulin receptor (Sus scrofa)
Created
Bevan, AP  (2003-07-31)
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