Insulin receptor signalling cascade

Stable Identifier
R-HSA-74751
Type
Pathway
Species
Homo sapiens
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Autophosphorylation of the insulin receptor triggers a series of signalling events, mediated by SHC or IRS, and resulting in activation of the Ras/RAF and MAP kinase cascades. A second effect of the autophosphorylation of the insulin receptor is its internalisation into an endosome, which downregulates its signalling activity.

Literature References
PubMed ID Title Journal Year
11282018 Insulin signalling.

Bevan, P

J Cell Sci 2001
9677303 Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling.

Shepherd, PR, Siddle, K, Withers, DJ

Biochem J 1998
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