Dissociation of insulin from insulin receptor

Stable Identifier
R-HSA-74726
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
endosome
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Dissociation of insulin from insulin receptor
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As the endosomal lumen acidifies the insulin dissociates from the insulin receptor making it available for degradation by the insulin degrading activity (IDA) present in the endosomal membrane.

Literature References
PubMed ID Title Journal Year
3061785 Insulin degradation: mechanisms, products, and significance.

Duckworth, WC

Endocr Rev 1989
9793760 Insulin degradation: progress and potential.

Duckworth, WC, Bennett, RG, Hamel, FG

Endocr Rev 1998
8682206 Endosomal proteolysis of internalized proteins.

Authier, F, Posner, BI, Bergeron, JJ

FEBS Lett 1996
Participants
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Participant Of
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Orthologous Events
Dissociation of insulin from insulin receptor (Canis familiaris)
Dissociation of insulin from insulin receptor (Danio rerio)
Dissociation of insulin from insulin receptor (Gallus gallus)
Dissociation of insulin from insulin receptor (Mus musculus)
Dissociation of insulin from insulin receptor (Rattus norvegicus)
Dissociation of insulin from insulin receptor (Xenopus tropicalis)
Authored
Bevan, AP  (2003-07-31)
Created
Bevan, AP  (2003-07-31)