Dissociation of insulin from insulin receptor

Stable Identifier
R-HSA-74726
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
endosome
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Dissociation of insulin from insulin receptor
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
As the endosomal lumen acidifies the insulin dissociates from the insulin receptor making it available for degradation by the insulin degrading activity (IDA) present in the endosomal membrane.
Literature References
PubMed ID Title Journal Year
9793760 Insulin degradation: progress and potential.

Duckworth, WC, Bennett, RG, Hamel, FG

Endocr Rev 1998
3061785 Insulin degradation: mechanisms, products, and significance.

Duckworth, WC

Endocr Rev 1989
8682206 Endosomal proteolysis of internalized proteins.

Bergeron, JJ, Authier, F, Posner, BI

FEBS Lett 1996
Participants
Input
Output
Participates
as an event of
Orthologous Events
Dissociation of insulin from insulin receptor (Bos taurus)
Dissociation of insulin from insulin receptor (Canis familiaris)
Dissociation of insulin from insulin receptor (Danio rerio)
Dissociation of insulin from insulin receptor (Gallus gallus)
Dissociation of insulin from insulin receptor (Mus musculus)
Dissociation of insulin from insulin receptor (Rattus norvegicus)
Dissociation of insulin from insulin receptor (Sus scrofa)
Dissociation of insulin from insulin receptor (Xenopus tropicalis)
Authored
Bevan, AP  (2003-07-31)
Created
Bevan, AP  (2003-07-31)
Cite Us!