Insulin binds the insulin receptor

Stable Identifier
R-HSA-74716
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Under normal physiological conditions blood glucose levels are kept under tight control by a series of regulated steps that ensure glucose homeostasis. Upon feeding glucose levels rise and in response to this the body secretes insulin from pancreatic beta-cells into the blood. At physiological concentrations insulin is present in the blood in its monomeric form. The insulin receptor is a tetramer, consisting of two alpha and two beta chains, which are produced by cleavage of a single translated peptide chain (Schenker & Kohanski 1991). Binding of insulin to its receptor occurs on the receptor alpha-subunits. There are two binding domains involved on the receptor (L1 and L2) and it is thought that the amino-terminus of insulin binds with L1 on one of the alpha-subunits and the carboxyterminus with L2 on the other alpha-subunit.

The binding of insulin to its receptor causes a conformational change in the alpha-subunits. This in turn produces a conformational change in the beta-subunits leading to the activation of the intrinsic insulin receptor tyrosine kinase.

Literature References
PubMed ID Title Journal Year
8276779 The insulin signaling system.

White, MF, Kahn, CR

J Biol Chem 1994
11737239 Surfing the insulin signaling web.

Van Obberghen, E, Baron, V, Delahaye, L, Emanuelli, B, Filippa, N, Giorgetti-Peraldi, S, Lebrun, P, Mothe-Satney, I, Peraldi, P, Rocchi, S, Sawka-Verhelle, D, Tartare-Deckert, S, Giudicelli, J

Eur J Clin Invest 2001
7781591 Insulin action and the insulin signaling network.

Cheatham, B, Kahn, CR

Endocr Rev 1995
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