Phosphorylation of IRS

Stable Identifier
Reaction [transition]
Homo sapiens
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At the beginning of this reaction, 1 molecule of 'ATP', and 1 molecule of 'IRS:activated insulin receptor' are present. At the end of this reaction, 1 molecule of 'phospho-IRS:activated insulin receptor', and 1 molecule of 'ADP' are present.

This reaction takes place on the 'internal side of plasma membrane' and is mediated by the 'transmembrane receptor protein tyrosine kinase activity' of 'IRS:activated insulin receptor'.

Literature References
PubMed ID Title Journal Year
16814735 siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle

Al-Khalili, L, Krook, A, Zhang, BB, Bouzakri, K, Zachrisson, A, Zierath, JR, Koistinen, HA

Cell Metab. 2006
Catalyst Activity

transmembrane receptor protein tyrosine kinase activity of IRS:Insulin:p-6Y-Insulin receptor [plasma membrane]

Orthologous Events
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