Phosphorylation of IRS

Stable Identifier
R-HSA-74711
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Phosphorylation of IRS
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
At the beginning of this reaction, 1 molecule of 'ATP', and 1 molecule of 'IRS:activated insulin receptor' are present. At the end of this reaction, 1 molecule of 'phospho-IRS:activated insulin receptor', and 1 molecule of 'ADP' are present.

This reaction takes place on the 'internal side of plasma membrane' and is mediated by the 'transmembrane receptor protein tyrosine kinase activity' of 'IRS:activated insulin receptor'.
Literature References
PubMed ID Title Journal Year
16814735 siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle

Al-Khalili, L, Krook, A, Zhang, BB, Bouzakri, K, Zachrisson, A, Zierath, JR, Koistinen, HA

Cell Metab. 2006
Participants
Input
Output
Participates
as an event of
Catalyst Activity

transmembrane receptor protein tyrosine kinase activity of IRS:Insulin:p-6Y-Insulin receptor [plasma membrane]

Physical Entity
IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Homo sapiens)
Activity
transmembrane receptor protein tyrosine kinase activity (GO:0004714)
Orthologous Events
Phosphorylation of IRS (Bos taurus)
Phosphorylation of IRS (Canis familiaris)
Phosphorylation of IRS (Gallus gallus)
Phosphorylation of IRS (Mus musculus)
Phosphorylation of IRS (Rattus norvegicus)
Phosphorylation of IRS (Sus scrofa)
Phosphorylation of IRS (Xenopus tropicalis)
Created
Bevan, AP  (2003-07-31)
Cite Us!