Phosphorylation of IRS

Stable Identifier
R-HSA-74711
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
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At the beginning of this reaction, 1 molecule of 'ATP', and 1 molecule of 'IRS:activated insulin receptor' are present. At the end of this reaction, 1 molecule of 'phospho-IRS:activated insulin receptor', and 1 molecule of 'ADP' are present.

This reaction takes place on the 'internal side of plasma membrane' and is mediated by the 'transmembrane receptor protein tyrosine kinase activity' of 'IRS:activated insulin receptor'.

Literature References
PubMed ID Title Journal Year
16814735 siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle

Bouzakri, K, Zachrisson, A, Al-Khalili, L, Zhang, BB, Koistinen, HA, Krook, A, Zierath, JR

Cell Metab. 2006
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
transmembrane receptor protein tyrosine kinase activity of IRS:Insulin:p-6Y-Insulin receptor [plasma membrane]
Physical Entity
Activity
Orthologous Events
Created