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OXCT1 [mitochondrial matrix]
Stable Identifier
R-HSA-74317
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
3-oxoacid CoA-transferase monomer, Succinyl-CoA:3-ketoacid-coenzyme A transferase, mitochondrial precursor , Succinyl CoA:3-oxoacid CoA-transferase
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Ketone body metabolism (Homo sapiens)
Utilization of Ketone Bodies (Homo sapiens)
OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Homo sapiens)
OXCT dimers [mitochondrial matrix] (Homo sapiens)
OXCT1 dimer [mitochondrial matrix] (Homo sapiens)
OXCT1 [mitochondrial matrix] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Mitochondrial protein degradation (Homo sapiens)
CLPXP binds mitochondrial matrix proteins (Homo sapiens)
CLPXP:substrate protein (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
Substrate of CLPXP (mitrochondrial matrix) [mitochondrial matrix] (Homo sapiens)
OXCT1 [mitochondrial matrix] (Homo sapiens)
Substrate of CLPXP (mitrochondrial matrix) [mitochondrial matrix] (Homo sapiens)
OXCT1 [mitochondrial matrix] (Homo sapiens)
CLPXP degrades mitochondrial matrix proteins (Homo sapiens)
CLPXP:substrate protein (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
Substrate of CLPXP (mitrochondrial matrix) [mitochondrial matrix] (Homo sapiens)
OXCT1 [mitochondrial matrix] (Homo sapiens)
LONP1 binds mitochondrial matrix proteins (Homo sapiens)
LONP1:substrate protein (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
Substrate of LONP1 (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
OXCT1 [mitochondrial matrix] (Homo sapiens)
Substrate of LONP1 (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
OXCT1 [mitochondrial matrix] (Homo sapiens)
LONP1 degrades mitochondrial matrix proteins (Homo sapiens)
LONP1:substrate protein (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
Substrate of LONP1 (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
OXCT1 [mitochondrial matrix] (Homo sapiens)
External Reference Information
External Reference
UniProt:P55809 OXCT1
Gene Names
OXCT1, OXCT, SCOT
Chain
transit peptide:1-39, chain:40-520
Reference Genes
BioGPS Gene:5019 OXCT1
COSMIC - genes:OXCT1 OXCT1
CTD Gene:5019 OXCT1
dbSNP Gene:5019 OXCT1
ENSEMBL:ENSG00000083720 OXCT1
HGNC:8527 OXCT1
KEGG:hsa:5019 OXCT1
Monarch:5019 OXCT1
NCBI Gene:5019 OXCT1
OMIM:601424 OXCT1
UCSC:P55809 OXCT1
Reference Transcript
RefSeq:NM_000436.4 OXCT1
Other Identifiers
11745194_a_at
11746434_a_at
11749874_a_at
16995809
202780_PM_at
202780_at
2855063
2855064
2855065
2855067
2855068
2855069
2855074
2855075
2855077
2855078
2855079
2855085
2855086
2855089
2855090
2855091
2855099
2855100
2855101
2855102
2855103
2855104
2855105
2855112
2855113
2855114
41142_at
5019
8111892
A_32_P63848
GE62044
GO:0005739
GO:0005759
GO:0006629
GO:0007507
GO:0007584
GO:0008260
GO:0008410
GO:0009410
GO:0009725
GO:0014823
GO:0016740
GO:0035774
GO:0042182
GO:0042594
GO:0042802
GO:0045471
GO:0046952
GO:0048856
GO:0060612
GO:1902224
HMNXSV003011808
HMNXSV003018884
ILMN_1813544
PH_hs_0010551
TC05001307.hg
U62961_at
g4557816_3p_at
Participates
as a member of
Substrate of LONP1 (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
Substrate of CLPXP (mitrochondrial matrix) [mitochondrial matrix] (Homo sapiens)
as a component of
OXCT1 dimer [mitochondrial matrix] (Homo sapiens)
Inferred To
oxct1a [mitochondrial matrix]
(Danio rerio)
oxct1 [mitochondrial matrix]
(Dictyostelium discoideum)
oxct1 [mitochondrial matrix]
(Xenopus tropicalis)
Oxct1 [mitochondrial matrix]
(Mus musculus)
Oxct1 [mitochondrial matrix]
(Rattus norvegicus)
Scot [mitochondrial matrix]
(Drosophila melanogaster)
OXCT1 [mitochondrial matrix]
(Bos taurus)
OXCT1 [mitochondrial matrix]
(Caenorhabditis elegans)
OXCT1 [mitochondrial matrix]
(Canis familiaris)
OXCT1 [mitochondrial matrix]
(Gallus gallus)
OXCT1 [mitochondrial matrix]
(Sus scrofa)
Cross References
RefSeq
NP_000427.1
ENSEMBL
ENSP00000196371
,
ENST00000512084
,
ENSG00000083720
,
ENST00000196371
,
ENSP00000421143
,
ENST00000510634
,
ENSP00000423144
OpenTargets
ENSG00000083720
GeneCards
OXCT1
HPA
ENSG00000083720-OXCT1
PRO
P55809
Pharos - Targets
P55809
GlyGen
P55809
Orphanet
OXCT1
HMDB Protein
HMDBP00712
PDB
3DLX
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P42566 EPS15
2
EPS15 [cytosol]
(R-HSA-182920)
p-Y849 EPS15 [cytosol]
(R-HSA-8867028)
0.527
2
UniProt:P10636-8 MAPT
3
MAPT-8 [cytosol]
(R-HSA-9619519)
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
0.527
4
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