HMG CoA => acetoacetic acid + acetyl CoA

Stable Identifier
R-HSA-74180
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
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HMG CoA => acetoacetic acid + acetyl CoA
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Hydroxymethylglutaryl-CoA lyase dimer (HMGCL) in the mitochondrial matrix catalyzes the reaction of beta-hydroxy-beta-methylglutaryl coenzyme A (HMG CoA) to form acetyl-CoA and acetoacetate (Mitchell et al. 1993).

Literature References
PubMed ID Title Journal Year
8440722 3-Hydroxy-3-methylglutaryl coenzyme A lyase (HL). Cloning of human and chicken liver HL cDNAs and characterization of a mutation causing human HL deficiency.

Mitchell, GA, Robert, MF, Hruz, PW, Wang, S, Fontaine, G, Behnke, CE, Mende-Mueller, LM, Schappert, K, Lee, C, Gibson, KM, Miziorko, HM

J Biol Chem 1993
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
hydroxymethylglutaryl-CoA lyase activity of HMGCL dimer [mitochondrial matrix]
Physical Entity
HMGCL dimer [mitochondrial matrix]
Activity
hydroxymethylglutaryl-CoA lyase activity (0004419)
Orthologous Events
HMG CoA => acetoacetic acid + acetyl CoA (Caenorhabditis elegans)
HMG CoA => acetoacetic acid + acetyl CoA (Canis familiaris)
HMG CoA => acetoacetic acid + acetyl CoA (Danio rerio)
HMG CoA => acetoacetic acid + acetyl CoA (Dictyostelium discoideum)
HMG CoA => acetoacetic acid + acetyl CoA (Drosophila melanogaster)
HMG CoA => acetoacetic acid + acetyl CoA (Mus musculus)
HMG CoA => acetoacetic acid + acetyl CoA (Rattus norvegicus)
HMG CoA => acetoacetic acid + acetyl CoA (Sus scrofa)
HMG CoA => acetoacetic acid + acetyl CoA (Xenopus tropicalis)
Cross References
Rhea
Created
Gopinathrao, G  (2003-07-16)
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