Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
ACA [mitochondrial matrix]
Stable Identifier
R-ALL-73909
Type
Chemical Compound [SimpleEntity]
Compartment
mitochondrial matrix
Synonyms
acetoacetate, acetoacetic acid
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Rattus norvegicus
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Metabolism (Bos taurus)
Metabolism of lipids (Bos taurus)
Ketone body metabolism (Bos taurus)
Synthesis of Ketone Bodies (Bos taurus)
HMG CoA => acetoacetic acid + acetyl CoA (Bos taurus)
ACA [mitochondrial matrix]
acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Bos taurus)
ACA [mitochondrial matrix]
Utilization of Ketone Bodies (Bos taurus)
D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Bos taurus)
ACA [mitochondrial matrix]
OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Bos taurus)
ACA [mitochondrial matrix]
Metabolism (Caenorhabditis elegans)
Metabolism of lipids (Caenorhabditis elegans)
Ketone body metabolism (Caenorhabditis elegans)
Synthesis of Ketone Bodies (Caenorhabditis elegans)
HMG CoA => acetoacetic acid + acetyl CoA (Caenorhabditis elegans)
ACA [mitochondrial matrix]
Utilization of Ketone Bodies (Caenorhabditis elegans)
OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Caenorhabditis elegans)
ACA [mitochondrial matrix]
Metabolism (Canis familiaris)
Metabolism of lipids (Canis familiaris)
Ketone body metabolism (Canis familiaris)
Synthesis of Ketone Bodies (Canis familiaris)
HMG CoA => acetoacetic acid + acetyl CoA (Canis familiaris)
ACA [mitochondrial matrix]
acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Canis familiaris)
ACA [mitochondrial matrix]
Utilization of Ketone Bodies (Canis familiaris)
D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Canis familiaris)
ACA [mitochondrial matrix]
OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Canis familiaris)
ACA [mitochondrial matrix]
Metabolism (Danio rerio)
Metabolism of lipids (Danio rerio)
Ketone body metabolism (Danio rerio)
Synthesis of Ketone Bodies (Danio rerio)
HMG CoA => acetoacetic acid + acetyl CoA (Danio rerio)
ACA [mitochondrial matrix]
acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Danio rerio)
ACA [mitochondrial matrix]
Utilization of Ketone Bodies (Danio rerio)
D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Danio rerio)
ACA [mitochondrial matrix]
OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Danio rerio)
ACA [mitochondrial matrix]
Metabolism (Dictyostelium discoideum)
Metabolism of lipids (Dictyostelium discoideum)
Ketone body metabolism (Dictyostelium discoideum)
Synthesis of Ketone Bodies (Dictyostelium discoideum)
HMG CoA => acetoacetic acid + acetyl CoA (Dictyostelium discoideum)
ACA [mitochondrial matrix]
Utilization of Ketone Bodies (Dictyostelium discoideum)
OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Dictyostelium discoideum)
ACA [mitochondrial matrix]
Metabolism (Drosophila melanogaster)
Metabolism of lipids (Drosophila melanogaster)
Ketone body metabolism (Drosophila melanogaster)
Synthesis of Ketone Bodies (Drosophila melanogaster)
HMG CoA => acetoacetic acid + acetyl CoA (Drosophila melanogaster)
ACA [mitochondrial matrix]
acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Drosophila melanogaster)
ACA [mitochondrial matrix]
Utilization of Ketone Bodies (Drosophila melanogaster)
D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Drosophila melanogaster)
ACA [mitochondrial matrix]
OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Drosophila melanogaster)
ACA [mitochondrial matrix]
Metabolism (Gallus gallus)
Metabolism of lipids (Gallus gallus)
Ketone body metabolism (Gallus gallus)
Synthesis of Ketone Bodies (Gallus gallus)
HMG CoA => acetoacetic acid + acetyl CoA (Gallus gallus)
ACA [mitochondrial matrix]
acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Gallus gallus)
ACA [mitochondrial matrix]
Utilization of Ketone Bodies (Gallus gallus)
D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Gallus gallus)
ACA [mitochondrial matrix]
OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Gallus gallus)
ACA [mitochondrial matrix]
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Ketone body metabolism (Homo sapiens)
Synthesis of Ketone Bodies (Homo sapiens)
HMG CoA => acetoacetic acid + acetyl CoA (Homo sapiens)
ACA [mitochondrial matrix]
acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Homo sapiens)
ACA [mitochondrial matrix]
Utilization of Ketone Bodies (Homo sapiens)
D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Homo sapiens)
ACA [mitochondrial matrix]
OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Homo sapiens)
ACA [mitochondrial matrix]
Metabolism (Mus musculus)
Metabolism of lipids (Mus musculus)
Ketone body metabolism (Mus musculus)
Synthesis of Ketone Bodies (Mus musculus)
HMG CoA => acetoacetic acid + acetyl CoA (Mus musculus)
ACA [mitochondrial matrix]
acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Mus musculus)
ACA [mitochondrial matrix]
Utilization of Ketone Bodies (Mus musculus)
D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Mus musculus)
ACA [mitochondrial matrix]
OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Mus musculus)
ACA [mitochondrial matrix]
Metabolism (Rattus norvegicus)
Metabolism of lipids (Rattus norvegicus)
Ketone body metabolism (Rattus norvegicus)
Synthesis of Ketone Bodies (Rattus norvegicus)
HMG CoA => acetoacetic acid + acetyl CoA (Rattus norvegicus)
ACA [mitochondrial matrix]
acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Rattus norvegicus)
ACA [mitochondrial matrix]
Utilization of Ketone Bodies (Rattus norvegicus)
D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Rattus norvegicus)
ACA [mitochondrial matrix]
OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Rattus norvegicus)
ACA [mitochondrial matrix]
Metabolism (Schizosaccharomyces pombe)
Metabolism of lipids (Schizosaccharomyces pombe)
Ketone body metabolism (Schizosaccharomyces pombe)
Synthesis of Ketone Bodies (Schizosaccharomyces pombe)
acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Schizosaccharomyces pombe)
ACA [mitochondrial matrix]
Utilization of Ketone Bodies (Schizosaccharomyces pombe)
D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Schizosaccharomyces pombe)
ACA [mitochondrial matrix]
Metabolism (Sus scrofa)
Metabolism of lipids (Sus scrofa)
Ketone body metabolism (Sus scrofa)
Synthesis of Ketone Bodies (Sus scrofa)
HMG CoA => acetoacetic acid + acetyl CoA (Sus scrofa)
ACA [mitochondrial matrix]
acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Sus scrofa)
ACA [mitochondrial matrix]
Utilization of Ketone Bodies (Sus scrofa)
D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Sus scrofa)
ACA [mitochondrial matrix]
OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Sus scrofa)
ACA [mitochondrial matrix]
Metabolism (Xenopus tropicalis)
Metabolism of lipids (Xenopus tropicalis)
Ketone body metabolism (Xenopus tropicalis)
Synthesis of Ketone Bodies (Xenopus tropicalis)
HMG CoA => acetoacetic acid + acetyl CoA (Xenopus tropicalis)
ACA [mitochondrial matrix]
acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Xenopus tropicalis)
ACA [mitochondrial matrix]
Utilization of Ketone Bodies (Xenopus tropicalis)
D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Xenopus tropicalis)
ACA [mitochondrial matrix]
OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Xenopus tropicalis)
ACA [mitochondrial matrix]
External Reference Information
External Reference
acetoacetic acid [ChEBI:15344]
Participates
as an input of
OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Homo sapiens)
acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Homo sapiens)
OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Mus musculus)
OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Rattus norvegicus)
OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Canis familiaris)
OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Bos taurus)
OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Sus scrofa)
OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Danio rerio)
OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Xenopus tropicalis)
OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Gallus gallus)
OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Drosophila melanogaster)
OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Caenorhabditis elegans)
OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Dictyostelium discoideum)
acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Mus musculus)
acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Rattus norvegicus)
acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Canis familiaris)
acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Bos taurus)
acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Sus scrofa)
acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Danio rerio)
acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Xenopus tropicalis)
acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Gallus gallus)
acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Drosophila melanogaster)
acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Schizosaccharomyces pombe)
as an output of
HMG CoA => acetoacetic acid + acetyl CoA (Homo sapiens)
D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Mus musculus)
D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Rattus norvegicus)
D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Canis familiaris)
D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Bos taurus)
D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Sus scrofa)
D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Danio rerio)
D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Xenopus tropicalis)
D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Gallus gallus)
D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Drosophila melanogaster)
HMG CoA => acetoacetic acid + acetyl CoA (Mus musculus)
HMG CoA => acetoacetic acid + acetyl CoA (Rattus norvegicus)
HMG CoA => acetoacetic acid + acetyl CoA (Canis familiaris)
HMG CoA => acetoacetic acid + acetyl CoA (Bos taurus)
HMG CoA => acetoacetic acid + acetyl CoA (Sus scrofa)
HMG CoA => acetoacetic acid + acetyl CoA (Danio rerio)
HMG CoA => acetoacetic acid + acetyl CoA (Xenopus tropicalis)
HMG CoA => acetoacetic acid + acetyl CoA (Gallus gallus)
HMG CoA => acetoacetic acid + acetyl CoA (Drosophila melanogaster)
HMG CoA => acetoacetic acid + acetyl CoA (Caenorhabditis elegans)
HMG CoA => acetoacetic acid + acetyl CoA (Dictyostelium discoideum)
D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Homo sapiens)
D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Schizosaccharomyces pombe)
Other forms of this molecule
ACA [extracellular region]
Cross References
Guide to Pharmacology
4522
COMPOUND
C00164
PubChem Substance
7985318
HMDB Metabolite
HMDB0000060
ZINC
ZINC000000895089
© 2025
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
