cGMP binds CNG channel to form cGMP:CNG channel

Stable Identifier
R-HSA-74031
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Once cGMP concentration is restored to "dark" levels, it binds cooperatively to the cGMP-gated cation channel (CNG channel), inducing opening through a conformational change in the channel (open status designated as cGMP:CNG channel here) (Chen et al 1993, Dhallan et al. 1992).

Literature References
PubMed ID Title Journal Year
7682292 A new subunit of the cyclic nucleotide-gated cation channel in retinal rods

Chen, TY, Peng, YW, Dhallan, RS, Ahamed, B, Reed, RR, Yau, KW

Nature 1993
1379636 Human rod photoreceptor cGMP-gated channel: amino acid sequence, gene structure, and functional expression.

Dhallan, RS, Macke, JP, Shows, TB, Reed, RR, Yau, KW, Nathans, J

J Neurosci 1992
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created
Cite Us!