Monomeric caspase-8 zymogens undergo dimerization and subsequent conformational changes at the FASL:FAS Receptor Trimer:FADD:procaspase-8 receptor complex leading to the formation of the catalytically active form of procaspase-8.
Hughes, MA, Harper, N, Butterworth, M, Cain, K, Cohen, GM, MacFarlane, M
Chang, DW, Xing, Z, Capacio, VL, Peter, ME, Yang, X
Ashkenazi, A, Dixit, VM
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