FAS-mediated dimerization of procaspase-8

Stable Identifier
R-HSA-73945
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
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FAS-mediated dimerization of procaspase-8
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Monomeric caspase-8 zymogens undergo dimerization and subsequent conformational changes at the FASL:FAS Receptor Trimer:FADD:procaspase-8 receptor complex leading to the formation of the catalytically active form of procaspase-8.

Literature References
PubMed ID Title Journal Year
19683492 Reconstitution of the death-inducing signaling complex reveals a substrate switch that determines CD95-mediated death or survival

Hughes, MA, Harper, N, Butterworth, M, Cain, K, Cohen, GM, MacFarlane, M

Mol. Cell 2009
12912912 Interdimer processing mechanism of procaspase-8 activation

Chang, DW, Xing, Z, Capacio, VL, Peter, ME, Yang, X

EMBO J 2003
9721089 Death receptors: signaling and modulation

Ashkenazi, A, Dixit, VM

Science 1998
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
FLIP(S) [cytosol] (Homo sapiens)
Orthologous Events
FAS-mediated dimerization of procaspase-8 (Bos taurus)
FAS-mediated dimerization of procaspase-8 (Canis familiaris)
FAS-mediated dimerization of procaspase-8 (Danio rerio)
FAS-mediated dimerization of procaspase-8 (Gallus gallus)
FAS-mediated dimerization of procaspase-8 (Mus musculus)
FAS-mediated dimerization of procaspase-8 (Rattus norvegicus)
FAS-mediated dimerization of procaspase-8 (Sus scrofa)
FAS-mediated dimerization of procaspase-8 (Xenopus tropicalis)
Reviewed
Gillespie, ME  (2012-11-19)
Pop, C  (2013-05-22)
Salvesen, GS  (2013-05-22)
Created
Tschopp, J  (2004-01-28)
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