FAS-mediated dimerization of procaspase-8

Stable Identifier
Reaction [binding]
Homo sapiens
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Monomeric caspase-8 zymogens undergo dimerization and subsequent conformational changes at the FASL:FAS Receptor Trimer:FADD:procaspase-8 receptor complex leading to the formation of the catalytically active form of procaspase-8.

Literature References
PubMed ID Title Journal Year
19683492 Reconstitution of the death-inducing signaling complex reveals a substrate switch that determines CD95-mediated death or survival

Hughes, MA, Harper, N, Butterworth, M, Cain, K, Cohen, GM, MacFarlane, M

Mol. Cell 2009
12912912 Interdimer processing mechanism of procaspase-8 activation

Chang, DW, Xing, Z, Capacio, VL, Peter, ME, Yang, X

EMBO J 2003
9721089 Death receptors: signaling and modulation

Ashkenazi, A, Dixit, VM

Science 1998
Participant Of
This event is regulated
Negatively by
Orthologous Events