FAS-mediated dimerization of procaspase-8

Stable Identifier
R-HSA-73945
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
FAS-mediated dimerization of procaspase-8
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Monomeric caspase-8 zymogens undergo dimerization and subsequent conformational changes at the FASL:FAS Receptor Trimer:FADD:procaspase-8 receptor complex leading to the formation of the catalytically active form of procaspase-8.

Literature References
PubMed ID Title Journal Year
19683492 Reconstitution of the death-inducing signaling complex reveals a substrate switch that determines CD95-mediated death or survival

Hughes, MA, Harper, N, Butterworth, M, Cain, K, Cohen, GM, MacFarlane, M

Mol. Cell 2009
12912912 Interdimer processing mechanism of procaspase-8 activation

Chang, DW, Xing, Z, Capacio, VL, Peter, ME, Yang, X

EMBO J 2003
9721089 Death receptors: signaling and modulation

Ashkenazi, A, Dixit, VM

Science 1998
Participants
Input
Output
Participant Of
hasEvent
This event is regulated
Negatively by
Orthologous Events
FAS-mediated dimerization of procaspase-8 (Bos taurus)
FAS-mediated dimerization of procaspase-8 (Canis familiaris)
FAS-mediated dimerization of procaspase-8 (Danio rerio)
FAS-mediated dimerization of procaspase-8 (Gallus gallus)
FAS-mediated dimerization of procaspase-8 (Mus musculus)
FAS-mediated dimerization of procaspase-8 (Rattus norvegicus)
FAS-mediated dimerization of procaspase-8 (Sus scrofa)
FAS-mediated dimerization of procaspase-8 (Xenopus tropicalis)
Reviewed
Gillespie, ME  (2012-11-19)
Pop, C  (2013-05-22)
Salvesen, GS  (2013-05-22)
Created
Tschopp, J  (2004-01-28)