Dimerization of procaspase-8

Stable Identifier
R-HSA-69416
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Dimerization of procaspase-8
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Procaspase-8 monomers undergo dimerization. The dimerization event occurs at death-inducing signaling complex (DISC) and results in a reposition of the procaspase-8 inter-subunit linker to become accessible for intermolecular processing by the associated procaspase-8 molecule [Keller N et al 2010; Oberst A et al 2010].
Literature References
PubMed ID Title Journal Year
20308068 Inducible dimerization and inducible cleavage reveal a requirement for both processes in caspase-8 activation

Blais, V, Oberst, A, Denault, JB, Green, DR, Salvesen, GS, Tremblay, AG, Pop, C

J Biol Chem 2010
12620240 Insights into the regulatory mechanism for caspase-8 activation

Grütter, MG, Briand, C, Mac Sweeney, A, Donepudi, M

Mol. Cell 2003
19851329 Studies of the molecular mechanism of caspase-8 activation by solution NMR

Grütter, MG, Keller, N, Zerbe, O

Cell Death Differ. 2010
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Event Information
Go Biological Process
activation of cysteine-type endopeptidase activity involved in apoptotic process (0006919)
Orthologous Events
Dimerization of procaspase-8 (Bos taurus)
Dimerization of procaspase-8 (Canis familiaris)
Dimerization of procaspase-8 (Gallus gallus)
Dimerization of procaspase-8 (Mus musculus)
Dimerization of procaspase-8 (Rattus norvegicus)
Dimerization of procaspase-8 (Sus scrofa)
Cross References
BioModels Database
Reviewed
Gillespie, ME  (2012-11-19)
Salvesen, GS  (2013-05-22)
Pop, C  (2013-05-22)
Created
Tschopp, J  (2004-01-28)
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