Procaspase-8 monomers undergo dimerization. The dimerization event occurs at death-inducing signaling complex (DISC) and results in a reposition of the procaspase-8 inter-subunit linker to become accessible for intermolecular processing by the associated procaspase-8 molecule [Keller N et al 2010; Oberst A et al 2010].
Donepudi, M, Mac Sweeney, A, Briand, C, Grütter, MG
Oberst, A, Pop, C, Tremblay, AG, Blais, V, Denault, JB, Salvesen, GS, Green, DR
Keller, N, Grütter, MG, Zerbe, O
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