Reactome | Dimerization of procaspase-8

Dimerization of procaspase-8

Stable Identifier

R-HSA-69416

Type

Pathway

Species

Homo sapiens

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Procaspase-8 monomers undergo dimerization. The dimerization event occurs at death-inducing signaling complex (DISC) and results in a reposition of the procaspase-8 inter-subunit linker to become accessible for intermolecular processing by the associated procaspase-8 molecule [Keller N et al 2010; Oberst A et al 2010].

Literature References

PubMed ID	Title	Journal	Year
12620240	Insights into the regulatory mechanism for caspase-8 activation Donepudi, M, Mac Sweeney, A, Briand, C, Grütter, MG	Mol. Cell	2003
20308068	Inducible dimerization and inducible cleavage reveal a requirement for both processes in caspase-8 activation Oberst, A, Pop, C, Tremblay, AG, Blais, V, Denault, JB, Salvesen, GS, Green, DR	J Biol Chem	2010
19851329	Studies of the molecular mechanism of caspase-8 activation by solution NMR Keller, N, Grütter, MG, Zerbe, O	Cell Death Differ.	2010