Procaspase-8 monomers undergo dimerization. The dimerization event occurs at death-inducing signaling complex (DISC) and results in a reposition of the procaspase-8 inter-subunit linker to become accessible for intermolecular processing by the associated procaspase-8 molecule [Keller N et al 2010; Oberst A et al 2010].
Blais, V, Oberst, A, Denault, JB, Green, DR, Salvesen, GS, Tremblay, AG, Pop, C
Grütter, MG, Briand, C, Mac Sweeney, A, Donepudi, M
Grütter, MG, Keller, N, Zerbe, O
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