Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
HMGCS2 [mitochondrial matrix]
Stable Identifier
R-HSA-56573
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
hydroxymethylglutaryl-CoA synthase , Hydroxymethylglutaryl-CoA synthase, mitochondrial precursor , HMG-CoA synthase, 3-hydroxy-3-methylglutaryl coenzyme A synthase
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Ketone body metabolism (Homo sapiens)
Synthesis of Ketone Bodies (Homo sapiens)
acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Homo sapiens)
HMGCS2 [mitochondrial matrix] (Homo sapiens)
Regulation of lipid metabolism by PPARalpha (Homo sapiens)
PPARA activates gene expression (Homo sapiens)
Expression of HMGCS2 (Homo sapiens)
HMGCS2 [mitochondrial matrix] (Homo sapiens)
External Reference Information
External Reference
UniProt:P54868 HMGCS2
Gene Names
HMGCS2
Chain
transit peptide:1-37, chain:38-508
Reference Genes
BioGPS Gene:3158 HMGCS2
COSMIC (genes):HMGCS2 HMGCS2
CTD Gene:3158 HMGCS2
dbSNP Gene:3158 HMGCS2
ENSEMBL:ENSG00000134240 HMGCS2
HGNC:5008 HMGCS2
KEGG Gene (Homo sapiens):3158 HMGCS2
Monarch:3158 HMGCS2
NCBI Gene:3158 HMGCS2
OMIM:600234 HMGCS2
UCSC:P54868 HMGCS2
Reference Transcript
RefSeq:NM_005518.3 HMGCS2
RefSeq:NM_001166107.1 HMGCS2
RefSeq:XM_011541313.1 HMGCS2
Other Identifiers
0005860059
11720533_a_at
16691627
204607_at
240110_at
2431032
2431033
2431035
2431036
2431038
2431041
2431042
2431044
2431047
2431050
2431051
2431056
2431057
2431058
2431059
2431060
3158
35345_at
7919055
79657_at
A_23_P103588
GE60087
GO:0003674
GO:0003824
GO:0004421
GO:0005575
GO:0005622
GO:0005737
GO:0005739
GO:0005759
GO:0006084
GO:0006091
GO:0006629
GO:0006694
GO:0006695
GO:0006790
GO:0008150
GO:0008202
GO:0008203
GO:0008299
GO:0009058
GO:0010142
GO:0016126
GO:0016740
GO:0016746
GO:0019216
GO:0034641
GO:0042802
GO:0043226
GO:0044281
GO:0046951
GO:0051186
Hs.143969.0.A1_3p_at
ILMN_1815203
TC01003050.hg
X83618_at
g5031750_3p_at
Participant Of
output
Expression of HMGCS2
Inferred To
Hmgcs2 [mitochondrial matrix] (Mus musculus)
Hmgcs2 [mitochondrial matrix] (Rattus norvegicus)
hcs1 [mitochondrial matrix] (Schizosaccharomyces pombe)
Homologues of HMGCS2 [mitochondrial matrix] (Dictyostelium discoideum)
HMGCS2 [mitochondrial matrix] (Bos taurus)
HMGCS2 [mitochondrial matrix] (Canis familiaris)
HMGCS2 [mitochondrial matrix] (Gallus gallus)
HMGCS2 [mitochondrial matrix] (Sus scrofa)
Hmgs [mitochondrial matrix] (Drosophila melanogaster)
hmgcs1 [mitochondrial matrix] (Danio rerio)
hmgcs1 [mitochondrial matrix] (Xenopus tropicalis)
ERG13 [mitochondrial matrix] (Saccharomyces cerevisiae)
hgsA [mitochondrial matrix] (Dictyostelium discoideum)
hgsB [mitochondrial matrix] (Dictyostelium discoideum)
hmgs-1 [mitochondrial matrix] (Caenorhabditis elegans)
Cross References
RefSeq
NP_005509.1
,
XP_011539615.1
,
NP_001159579.1
OpenTargets
ENSG00000134240
GeneCards
P54868
HPA
ENSG00000134240-HMGCS2
Ensembl
ENSP00000358414
,
ENST00000544913
,
ENST00000369406
,
ENSP00000439495
,
ENSG00000134240
PRO
P54868
Orphanet
16209
HMDB Protein
HMDBP00040
PDB
2WYA
© 2021
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text