DNA Damage Bypass

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser
In addition to various processes for removing lesions from the DNA, cells have developed specific mechanisms for tolerating unrepaired damage during the replication of the genome. These mechanisms are collectively called DNA damage bypass pathways. The Y family of DNA polymerases plays a key role in DNA damage bypass.

Y family DNA polymerases, REV1, POLH (DNA polymerase eta), POLK (DNA polymerase kappa) and POLI (DNA polymerase iota), as well as the DNA polymerase zeta (POLZ) complex composed of REV3L and MAD2L2, are able to carry out translesion DNA synthesis (TLS) or replicative bypass of damaged bases opposite to template lesions that arrest high fidelity, highly processive replicative DNA polymerase complexes delta (POLD) and epsilon (POLE). REV1, POLH, POLK, POLI and POLZ lack 3'->5' exonuclease activity and exhibit low fidelity and weak processivity. The best established TLS mechanisms are annotated here. TLS details that require substantial experimental clarification have been omitted. For recent and past reviews of this topic, please refer to Lehmann 2000, Friedberg et al. 2001, Zhu and Zhang 2003, Takata and Wood 2009, Ulrich 2011, Saugar et al. 2014.

Literature References
PubMed ID Title Journal Year
25038291 Tolerating DNA damage during eukaryotic chromosome replication

Saugar, I, Tercero, JA, Ortiz-Bazán, MA

Exp. Cell Res. 2014
21605556 Timing and spacing of ubiquitin-dependent DNA damage bypass

Ulrich, HD

FEBS Lett. 2011
10925197 Replication of UV-damaged DNA: new insights into links between DNA polymerases, mutagenesis and human disease.

Lehmann, AR

Gene 2000
11595180 Error-prone DNA polymerases: novel structures and the benefits of infidelity.

Kisker, C, Friedberg, EC, Fischhaber, PL

Cell 2001
19225445 Bypass specialists operate together

Wood, RD, Takata, K

EMBO J. 2009
12800216 DNA polymerase zeta: new insight into eukaryotic mutagenesis and mammalian embryonic development.

Zhu, F, Zhang, M

World J Gastroenterol 2003
Event Information
Go Biological Process
Orthologous Events
Cite Us!