(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1)

Stable Identifier
R-HSA-75125
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1)
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Cytosolic UMP-CMP kinase (CMPK1) catalyzes the reversible reaction of CDP, dCDP, or UDP and ADP to form CMP, dCMP, or UMP and ATP (Liou et al. 2002; Scott and Wright 1979).
Literature References
PubMed ID Title Journal Year
11912132 Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates.

Lam, W, Cheng, YC, Jiang, Z, Liou, JY, Dutschman, GE

Cancer Res 2002
40615 Kinetics and equilibria of pyrimidine nucleoside monophosphate kinase from human erythrocytes

Wright, RC, Scott, EM

Biochim Biophys Acta 1979
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Event Information
Reverse Reaction
(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Homo sapiens)
Catalyst Activity

nucleoside monophosphate kinase activity of CMPK1, AK1 [cytosol]

Physical Entity
CMPK1, AK1 [cytosol] (Homo sapiens)
Activity
nucleoside monophosphate kinase activity (GO:0050145)
Orthologous Events
(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Bos taurus)
(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Caenorhabditis elegans)
(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Canis familiaris)
(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Danio rerio)
(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Dictyostelium discoideum)
(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Drosophila melanogaster)
(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Gallus gallus)
(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Mus musculus)
(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Plasmodium falciparum)
(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Rattus norvegicus)
(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Saccharomyces cerevisiae)
(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Schizosaccharomyces pombe)
(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Sus scrofa)
Cross References
Rhea
Created
D'Eustachio, P  (2003-08-25)
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