mRNA Editing: C to U Conversion

Stable Identifier
R-HSA-72200
Type
Pathway
Species
Homo sapiens
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The best characterized case of C to U editing is in the intestinal apolipoprotein B transcript, where the editing event creates a premature translation stop codon and consequently leads to a shorter form of the protein. In the liver, C to U editing is important in the expression of specific isoforms of the apolipoprotein B enzyme. ApoB mRNA editing is a posttranscriptional, nuclear process that can be initiated after splicing, at the time of polyadenylation and is completed by the time pre-mRNA matures fully (reviewed by Blanc and Davidson, 2003).
This editing event is a simple hydrolytic cytidine deamination to uridine, and is carried out by the Apobec-1 enzyme, along with the Apobec-1 complementing factor, ACF. The editing of apo-B mRNA involves the site-specific deamination of (C6666 to U), which converts codon 2153 from a glutamine codon, CAA, to a premature stop codon, UAA. As ACF is distributed in a variety of tissues, and these genes contain multiple family members, it is possible that editing events in additional targets will be found.
The cis-acting regulatory elements for C to U editing include: 22 nt editing site within ApoB mRNA, 5' tripartite motif with an enhancer element adjacent to the target cytidine, a spacer element and mooring sequence both 3' to the cytidine (reviewed by Smith et al., 1997).

Literature References
PubMed ID Title Journal Year
12446660 C-to-U RNA editing: mechanisms leading to genetic diversity.

Blanc, V, Davidson, NO

J Biol Chem 2003
12683974 Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business.

Wedekind, JE, Dance, GS, Sowden, MP, Smith, HC

Trends Genet 2003
11092837 Functions and mechanisms of RNA editing.

Gott, JM, Emeson, RB

Annu Rev Genet 2001
11072063 RNA editing: cytidine to uridine conversion in apolipoprotein B mRNA.

Chester, A, Scott, J, Anant, S, Navaratnam, N

Biochim Biophys Acta 2000
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