GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O

Stable Identifier
Reaction [transition]
Homo sapiens
2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O
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Cytosolic glutathione peroxidase (GPX1) tetramer catalyzes the reaction of reduced glutathione and hydrogen peroxide to form reduced glutathione and water (Chu et al. 1993).

Literature References
PubMed ID Title Journal Year
20070187 Irreversible inactivation of glutathione peroxidase 1 and reversible inactivation of peroxiredoxin II by H2O2 in red blood cells

Woo, HA, Cho, CS, Choi, EJ, Lee, GT, Rhee, SG, Lee, S

Antioxid. Redox Signal. 2010
3457020 Glutathione peroxidase protein. Absence in selenium deficiency states and correlation with enzymatic activity

Newburger, PE, Takahashi, K, Cohen, HJ

J. Clin. Invest. 1986
807573 Purification and properties of human erythrocyte glutathione peroxidase

Beutler, E, Srivastava, SK, Awasthi, YC

J. Biol. Chem. 1975
8428933 Expression, characterization, and tissue distribution of a new cellular selenium-dependent glutathione peroxidase, GSHPx-GI

Esworthy, RS, Chu, FF, Doroshow, JH

J Biol Chem 1993
Catalyst Activity

glutathione peroxidase activity of GPX1 tetramer [cytosol]

Orthologous Events
Cross References
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