2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O

Stable Identifier
R-HSA-71676
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O
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Cytosolic glutathione peroxidase (GPX1) tetramer catalyzes the reaction of reduced glutathione and hydrogen peroxide to form reduced glutathione and water (Chu et al. 1993).

Literature References
PubMed ID Title Journal Year
3457020 Glutathione peroxidase protein. Absence in selenium deficiency states and correlation with enzymatic activity

Takahashi, K, Newburger, PE, Cohen, HJ

J. Clin. Invest. 1986
20070187 Irreversible inactivation of glutathione peroxidase 1 and reversible inactivation of peroxiredoxin II by H2O2 in red blood cells

Cho, CS, Lee, S, Lee, GT, Woo, HA, Choi, EJ, Rhee, SG

Antioxid. Redox Signal. 2010
807573 Purification and properties of human erythrocyte glutathione peroxidase

Awasthi, YC, Beutler, E, Srivastava, SK

J. Biol. Chem. 1975
8428933 Expression, characterization, and tissue distribution of a new cellular selenium-dependent glutathione peroxidase, GSHPx-GI

Chu, FF, Doroshow, JH, Esworthy, RS

J Biol Chem 1993
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
glutathione peroxidase activity of GPX1 tetramer [cytosol]
Physical Entity
GPX1 tetramer [cytosol]
Activity
glutathione peroxidase activity (0004602)
Orthologous Events
2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Caenorhabditis elegans)
2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Canis familiaris)
2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Danio rerio)
2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Gallus gallus)
2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Mus musculus)
2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Rattus norvegicus)
2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Sus scrofa)
2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Xenopus tropicalis)
Cross References
Target Pathogen
Rhea
Authored
Vastrik, I  (2005-04-29)
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