Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
GYS2 [cytosol]
Stable Identifier
R-HSA-71599
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
glycogen synthase 2, Glycogen (starch) synthase, liver
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of metabolism (Homo sapiens)
Diseases of carbohydrate metabolism (Homo sapiens)
Glycogen storage diseases (Homo sapiens)
Glycogen storage disease type IV (GBE1) (Homo sapiens)
Defective GBE1 does not catalyze branch formation in growing glycogen chains (liver) (Homo sapiens)
polyGlc-GYG2:GYS2-a tetramer [cytosol] (Homo sapiens)
GYS2 [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glycogen metabolism (Homo sapiens)
Glycogen synthesis (Homo sapiens)
Autoglucosylation of GYG2 complexed with GYS2-a (Homo sapiens)
GYG2:GYS2-a tetramer [cytosol] (Homo sapiens)
GYS2 [cytosol] (Homo sapiens)
oligoGlc-GYG2:GYS2-a tetramer [cytosol] (Homo sapiens)
GYS2 [cytosol] (Homo sapiens)
EPM2A dimer binds PPP1R3C:phosphoglycogen-GYG2 complex (Homo sapiens)
EPM2A:PPP1R3C:phosphoglycogen-GYG2:GYS2-a tetramer [cytosol] (Homo sapiens)
GYS2 [cytosol] (Homo sapiens)
PPP1R3C:phosphoglycogen-GYG2:GYS2-a tetramer [cytosol] (Homo sapiens)
GYS2 [cytosol] (Homo sapiens)
EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Homo sapiens)
EPM2A:PPP1R3C:glycogen-GYG2:GYS2-a tetramer [cytosol] (Homo sapiens)
GYS2 [cytosol] (Homo sapiens)
EPM2A:PPP1R3C:phosphoglycogen-GYG2:GYS2-a tetramer [cytosol] (Homo sapiens)
GYS2 [cytosol] (Homo sapiens)
GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a (Homo sapiens)
glycogen-GYG2:GYS2-a tetramer [cytosol] (Homo sapiens)
GYS2 [cytosol] (Homo sapiens)
polyGlc-GYG2:GYS2-a tetramer [cytosol] (Homo sapiens)
GYS2 [cytosol] (Homo sapiens)
GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2 (Homo sapiens)
GYS2 [cytosol] (Homo sapiens)
PPP1R3C:glycogen-GYG2:GYS2-a tetramer [cytosol] (Homo sapiens)
GYS2 [cytosol] (Homo sapiens)
PPP1R3C:phosphoglycogen-GYG2:GYS2-a tetramer [cytosol] (Homo sapiens)
GYS2 [cytosol] (Homo sapiens)
GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2 (Homo sapiens)
GYS2 [cytosol] (Homo sapiens)
oligoGlc-GYG2:GYS2-a tetramer [cytosol] (Homo sapiens)
GYS2 [cytosol] (Homo sapiens)
polyGlc-GYG2:GYS2-a tetramer [cytosol] (Homo sapiens)
GYS2 [cytosol] (Homo sapiens)
NHLRC1 mediated ubiquitination of EPM2A (laforin) and PPP1RC3 (PTG) associated with glycogen-GYG2 (Homo sapiens)
EPM2A:PPP1R3C:glycogen-GYG2:GYS2-a tetramer [cytosol] (Homo sapiens)
GYS2 [cytosol] (Homo sapiens)
glycogen-GYG2:GYS2-a tetramer [cytosol] (Homo sapiens)
GYS2 [cytosol] (Homo sapiens)
PPP1R3C binds to glycogen:GYG2:GYS2 (Homo sapiens)
PPP1R3C:glycogen-GYG2:GYS2-a tetramer [cytosol] (Homo sapiens)
GYS2 [cytosol] (Homo sapiens)
glycogen-GYG2:GYS2-a tetramer [cytosol] (Homo sapiens)
GYS2 [cytosol] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
1731614
Comparative characterization of human and rat liver glycogen synthase.
Westphal, SA
,
Nuttall, FQ
Arch Biochem Biophys
1992
External Reference Information
External Reference
UniProt:P54840 GYS2
Gene Names
GYS2
Chain
chain:1-703
Reference Genes
BioGPS Gene:2998 GYS2
COSMIC (genes):GYS2 GYS2
CTD Gene:2998 GYS2
dbSNP Gene:2998 GYS2
ENSEMBL:ENSG00000111713 GYS2
HGNC:4707 GYS2
KEGG:hsa:2998 GYS2
Monarch:2998 GYS2
NCBI Gene:2998 GYS2
OMIM:138571 GYS2
UCSC:P54840 GYS2
Reference Transcript
RefSeq:NM_021957.3 GYS2
Other Identifiers
11725020_at
16762107
214621_PM_at
214621_at
2998
3446846
3446847
3446848
3446849
3446850
3446852
3446855
3446856
3446857
3446858
3446860
3446861
3446862
3446863
3446864
3446865
3446866
3446867
40682_at
7961673
A_23_P36621
A_33_P3360311
GE82630
GO:0003824
GO:0004373
GO:0005737
GO:0005829
GO:0005856
GO:0005938
GO:0005975
GO:0005978
GO:0006091
GO:0009749
GO:0016740
GO:0016757
GO:0030864
GO:0043226
GO:0061547
HMNXSV003030540
HMNXSV003031051
Hs.82614.0.S2_3p_at
ILMN_1807745
PH_hs_0004733
S70004_at
TC12001297.hg
TC12002789.hg
Participates
as a component of
EPM2A:PPP1R3C:glycogen-GYG2:GYS2-a tetramer [cytosol] (Homo sapiens)
GYG2:GYS2-a tetramer [cytosol] (Homo sapiens)
oligoGlc-GYG2:GYS2-a tetramer [cytosol] (Homo sapiens)
polyGlc-GYG2:GYS2-a tetramer [cytosol] (Homo sapiens)
glycogen-GYG2:GYS2-a tetramer [cytosol] (Homo sapiens)
PPP1R3C:glycogen-GYG2:GYS2-a tetramer [cytosol] (Homo sapiens)
EPM2A:PPP1R3C:phosphoglycogen-GYG2:GYS2-a tetramer [cytosol] (Homo sapiens)
PPP1R3C:phosphoglycogen-GYG2:GYS2-a tetramer [cytosol] (Homo sapiens)
Other forms of this molecule
GYS2 H446D [cytosol]
GYS2 N39S [cytosol]
p-S-GYS2 [cytosol]
Inferred To
GYS2 [cytosol]
(Bos taurus)
GYS2 [cytosol]
(Caenorhabditis elegans)
GYS2 [cytosol]
(Canis familiaris)
GYS2 [cytosol]
(Dictyostelium discoideum)
GYS2 [cytosol]
(Drosophila melanogaster)
GYS2 [cytosol]
(Gallus gallus)
GYS2 [cytosol]
(Saccharomyces cerevisiae)
GYS2 [cytosol]
(Sus scrofa)
Homologues of GYS2 [cytosol]
(Saccharomyces cerevisiae)
Cross References
ENSEMBL
ENSP00000261195
,
ENST00000261195
OpenTargets
ENSG00000111713
HPA
ENSG00000111713-GYS2
PRO
P54840
Pharos - Targets
P54840
GlyGen
P54840
Orphanet
GYS2
HMDB Protein
HMDBP01091
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text