D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate

Stable Identifier
R-HSA-71296
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate
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Cytosolic 6-phosphogluconolactonase (PGLS) catalyzes the hydrolysis of D-glucono-1,5-lactone 6-phosphate to form 6-phospho-D-gluconate (Beutler and Kuhl 1985; Collard et al. 1999).

Literature References
PubMed ID Title Journal Year
10518023 Identification of the cDNA encoding human 6-phosphogluconolactonase, the enzyme catalyzing the second step of the pentose phosphate pathway(1)

Collard, F, Collet, JF, Gerin, I, Veiga-da-Cunha, M, Van Schaftingen, E

FEBS Lett 1999
3932573 Limiting role of 6-phosphogluconolactonase in erythrocyte hexose monophosphate pathway metabolism

Kuhl, W, Beutler, E

J Lab Clin Med 1985
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Catalyst Activity

6-phosphogluconolactonase activity of PGLS [cytosol]

Physical Entity
PGLS [cytosol] (Homo sapiens)
Activity
6-phosphogluconolactonase activity (GO:0017057)
Orthologous Events
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Bos taurus)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Caenorhabditis elegans)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Canis familiaris)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Danio rerio)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Dictyostelium discoideum)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Drosophila melanogaster)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Gallus gallus)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Mus musculus)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Rattus norvegicus)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Saccharomyces cerevisiae)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Schizosaccharomyces pombe)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Sus scrofa)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Xenopus tropicalis)
Cross References
Rhea
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