D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate

Stable Identifier
R-HSA-71296
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cytosolic 6-phosphogluconolactonase (PGLS) catalyzes the hydrolysis of D-glucono-1,5-lactone 6-phosphate to form 6-phospho-D-gluconate (Beutler and Kuhl 1985; Collard et al. 1999).

Literature References
PubMed ID Title Journal Year
10518023 Identification of the cDNA encoding human 6-phosphogluconolactonase, the enzyme catalyzing the second step of the pentose phosphate pathway(1)

Collard, F, Collet, JF, Gerin, I, Veiga-da-Cunha, M, Van Schaftingen, E

FEBS Lett 1999
3932573 Limiting role of 6-phosphogluconolactonase in erythrocyte hexose monophosphate pathway metabolism

Kuhl, W, Beutler, E

J Lab Clin Med 1985
Participants
Input
Output
Participates
as an event of
Catalyst Activity

6-phosphogluconolactonase activity of PGLS [cytosol]

Physical Entity
PGLS [cytosol] (Homo sapiens)
Activity
6-phosphogluconolactonase activity (GO:0017057)
Orthologous Events
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Bos taurus)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Caenorhabditis elegans)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Canis familiaris)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Danio rerio)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Dictyostelium discoideum)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Drosophila melanogaster)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Gallus gallus)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Mus musculus)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Rattus norvegicus)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Saccharomyces cerevisiae)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Schizosaccharomyces pombe)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Sus scrofa)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Xenopus tropicalis)
Cross References
Rhea
Cite Us!