Reactome | PGLS hydrolyzes D-glucono-1,5-lactone 6-phosphate

PGLS hydrolyzes D-glucono-1,5-lactone 6-phosphate

Stable Identifier

R-HSA-71296

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate

ReviewStatus

5/5

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PGLS hydrolyzes D-glucono-1,5-lactone 6-phosphate

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Cytosolic 6-phosphogluconolactonase (PGLS) catalyzes the hydrolysis of D-glucono-1,5-lactone 6-phosphate to form 6-phospho-D-gluconate (Beutler and Kuhl 1985; Collard et al. 1999).

Literature References

PubMed ID	Title	Journal	Year
10518023	Identification of the cDNA encoding human 6-phosphogluconolactonase, the enzyme catalyzing the second step of the pentose phosphate pathway(1) Collard, F, Collet, JF, Gerin, I, Veiga-da-Cunha, M, Van Schaftingen, E	FEBS Lett	1999
3932573	Limiting role of 6-phosphogluconolactonase in erythrocyte hexose monophosphate pathway metabolism Beutler, E, Kuhl, W	J Lab Clin Med	1985