D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate

Stable Identifier
R-HSA-71296
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cytosolic 6-phosphogluconolactonase (PGLS) catalyzes the hydrolysis of D-glucono-1,5-lactone 6-phosphate to form 6-phospho-D-gluconate (Beutler and Kuhl 1985; Collard et al. 1999).

Literature References
PubMed ID Title Journal Year
3932573 Limiting role of 6-phosphogluconolactonase in erythrocyte hexose monophosphate pathway metabolism

Beutler, E, Kuhl, W

J Lab Clin Med 1985
10518023 Identification of the cDNA encoding human 6-phosphogluconolactonase, the enzyme catalyzing the second step of the pentose phosphate pathway(1)

Collard, F, Collet, JF, Gerin, I, Veiga-da-Cunha, M, Van Schaftingen, E

FEBS Lett 1999
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
6-phosphogluconolactonase activity of PGLS [cytosol]
Physical Entity
PGLS [cytosol]
Activity
6-phosphogluconolactonase activity (0017057)
Orthologous Events
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Caenorhabditis elegans)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Canis familiaris)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Danio rerio)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Dictyostelium discoideum)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Drosophila melanogaster)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Gallus gallus)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Mus musculus)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Rattus norvegicus)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Saccharomyces cerevisiae)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Schizosaccharomyces pombe)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Sus scrofa)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Xenopus tropicalis)
Cross References
Rhea