guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine

Stable Identifier
R-HSA-71286
Type
Reaction
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cytosolic guanidinoacetate methyltransferase catalyzes the reaction of S-adenosylmethionine and guanidinoacetate to form S-adenosylhomocysteine and creatine (Stockler et al. 1996).

Literature References
PubMed ID Title Journal Year
8651275 Guanidinoacetate methyltransferase deficiency: the first inborn error of creatine metabolism in man.

Isbrandt, D, Stockler, S, von Figura, K, Hanefeld, F, Schmidt, B

Am J Hum Genet 1996
Participants
Input
Output
Participates
as an event of
Catalyst Activity

methyltransferase activity of GAMT [cytosol]

Physical Entity
GAMT [cytosol] (Homo sapiens)
Activity
methyltransferase activity (GO:0008168)
Orthologous Events
guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Bos taurus)
guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Danio rerio)
guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Gallus gallus)
guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Mus musculus)
guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Rattus norvegicus)
guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Saccharomyces cerevisiae)
guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Schizosaccharomyces pombe)
guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Sus scrofa)
guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Xenopus tropicalis)
Cross References
Rhea
Cite Us!