guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine

Stable Identifier
R-HSA-71286
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine
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Cytosolic guanidinoacetate methyltransferase catalyzes the reaction of S-adenosylmethionine and guanidinoacetate to form S-adenosylhomocysteine and creatine (Stockler et al. 1996).

Literature References
PubMed ID Title Journal Year
8651275 Guanidinoacetate methyltransferase deficiency: the first inborn error of creatine metabolism in man.

Stockler, S, Isbrandt, D, Hanefeld, F, Schmidt, B, von Figura, K

Am J Hum Genet 1996
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
methyltransferase activity of GAMT [cytosol]
Physical Entity
GAMT [cytosol]
Activity
methyltransferase activity (0008168)
Orthologous Events
guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Bos taurus)
guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Canis familiaris)
guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Danio rerio)
guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Gallus gallus)
guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Mus musculus)
guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Rattus norvegicus)
guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Saccharomyces cerevisiae)
guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Schizosaccharomyces pombe)
guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Sus scrofa)
guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Xenopus tropicalis)
Cross References
Rhea
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