Succinate <=> Fumarate (with FAD redox reaction on enzyme)

Stable Identifier
R-HSA-70994
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
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The succinate dehydrogenase complex, associated with the inner mitochondrial membrane, catalyzes the dehydrogenation of succinate to fumarate, reducing the FAD cofactor bound to the enzyme. This redox potential is then used in the electron transfer chain to drive a proton motive force to generate ATP.

Literature References
PubMed ID Title Journal Year
16143825 Succinate dehydrogenase deficiency in human

Briere, JJ, Favier, J, El Ghouzzi, V, Djouadi, F, Benit, P, Gimenez, AP, Rustin, P

Cell Mol Life Sci 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
succinate dehydrogenase (ubiquinone) activity of SDH complex (ox.) [mitochondrial inner membrane]
Physical Entity
Activity
Orthologous Events