N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate

Stable Identifier
R-HSA-70920
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cytosolic formimidoyltransferase-cyclodeaminase (FTCD) catalyzes the reaction of N-formiminoglutamate and tetrahydrofolate to form glutamate and 5-formiminotetrahydrofolate. The gene encoding the human enzyme has beeen cloned and its sequence can encode a protein homologous the the biochemically characterized porcine protein (Solans et al. 2000; Murley et al. 1993). The function of FTCD in vivo was established by identification of missense mutations that reduce enzyme activity in patients with glutamate formiminotransferase deficiency (Hilton et al. 2003). Human FTCD is inferred to be an octamer by homology to the porcine enzyme (Murley et al. 1993).

Literature References
PubMed ID Title Journal Year
7901203 The nucleotide sequence of porcine formiminotransferase cyclodeaminase. Expression and purification from Escherichia coli.

Murley, LL, Mejia, NR, MacKenzie, RE

J Biol Chem 1993
12815595 The molecular basis of glutamate formiminotransferase deficiency

Hudson, TJ, Rosenblatt, DS, Hilton, JF, de la Luna, S, Christensen, KE, Watkins, D, Raby, BA, Estivill, X, MacKenzie, RE, Renaud, Y

Hum Mutat 2003
10773664 Cloning and characterization of human FTCD on 21q22.3, a candidate gene for glutamate formiminotransferase deficiency.

de la Luna, S, Solans, A, Estivill, X

Cytogenet Cell Genet 2000
Participants
Participates
Catalyst Activity

formimidoyltetrahydrofolate cyclodeaminase activity of FTCD octamer [cytosol]

Orthologous Events
Cross References
Rhea
Authored
Cite Us!