Reactome | N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate

N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate

Stable Identifier

R-HSA-70920

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

(6S)-5,6,7,8-tetrahydrofolate + N-formimidoyl-L-glutamate => 5-formimidoyltetrahydrofolate + L-glutamate

ReviewStatus

5/5

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N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate

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Cytosolic formimidoyltransferase-cyclodeaminase (FTCD) catalyzes the reaction of N-formiminoglutamate and tetrahydrofolate to form glutamate and 5-formiminotetrahydrofolate. The gene encoding the human enzyme has beeen cloned and its sequence can encode a protein homologous the the biochemically characterized porcine protein (Solans et al. 2000; Murley et al. 1993). The function of FTCD in vivo was established by identification of missense mutations that reduce enzyme activity in patients with glutamate formiminotransferase deficiency (Hilton et al. 2003). Human FTCD is inferred to be an octamer by homology to the porcine enzyme (Murley et al. 1993).

Literature References

PubMed ID	Title	Journal	Year
7901203	The nucleotide sequence of porcine formiminotransferase cyclodeaminase. Expression and purification from Escherichia coli. Murley, LL, Mejia, NR, MacKenzie, RE	J Biol Chem	1993
12815595	The molecular basis of glutamate formiminotransferase deficiency Hilton, JF, Christensen, KE, Watkins, D, Raby, BA, Renaud, Y, de la Luna, S, Estivill, X, MacKenzie, RE, Hudson, TJ, Rosenblatt, DS	Hum Mutat	2003
10773664	Cloning and characterization of human FTCD on 21q22.3, a candidate gene for glutamate formiminotransferase deficiency. Solans, A, Estivill, X, de la Luna, S	Cytogenet Cell Genet	2000