histidine => urocanate + NH4+

Stable Identifier
R-HSA-70899
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
L-histidine => NH4(+) + trans-urocanate
ReviewStatus
5/5
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histidine => urocanate + NH4+
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Cytosolic histidine ammonia lyase (HAL) catalyzes the reaction of histidine to form urocanate and NH4+ (Kawai et al. 2005).
Literature References
PubMed ID Title Journal Year
15806399 Molecular characterization of histidinemia: identification of four missense mutations in the histidase gene

Kawai, Y, Moriyama, A, Asai, K, Coleman-Campbell, CM, Sumi, S, Morishita, H, Suchi, M

Hum Genet 2005
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as an event of
Catalyst Activity

histidine ammonia-lyase activity of HAL [cytosol]

Physical Entity
HAL [cytosol] (Homo sapiens)
Activity
histidine ammonia-lyase activity (GO:0004397)
Orthologous Events
histidine => urocanate + NH4+ (Bos taurus)
histidine => urocanate + NH4+ (Caenorhabditis elegans)
histidine => urocanate + NH4+ (Canis familiaris)
histidine => urocanate + NH4+ (Danio rerio)
histidine => urocanate + NH4+ (Dictyostelium discoideum)
histidine => urocanate + NH4+ (Gallus gallus)
histidine => urocanate + NH4+ (Mus musculus)
histidine => urocanate + NH4+ (Rattus norvegicus)
histidine => urocanate + NH4+ (Sus scrofa)
histidine => urocanate + NH4+ (Xenopus tropicalis)
Cross References
RHEA
Authored
D'Eustachio, P  (2003-06-24)
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